Esamin 5% (IV Infusion)

500 ml bottle: ৳ 350.00

Medicine Details

Indications

  • Source of amino acids for protein synthesis
  • Suitable for patients with basal amino acid requirements
  • Faster recovery in surgery, burns, renal insufficiency, hepatic insufficiency, effective management of cancer

Composition

  • EssentialAminoAcids:
    • L-Isoleucine
    • L-Leucine
    • L-Lysine Hydrochloride
    • L-Methionine
    • L-Phenylalanine
    • L-Threonine
    • L-Tryptophan
    • L-Valine
    • L-Histidine
    • L-Tyrosine
  • NonEssentialAminoAcids:
    • L-Arginine
    • L-Aspartic Acid
    • L-Glutamic Acid
    • L-Alanine
    • L-Cystine
    • Glycine (Aminoacetic Acid)
    • L-Proline
    • L-Serine
  • Excipients:
    • D-Sorbitol
  • Electrolytes:
    • Sodium (Na+)
    • Potassium (K+)
    • Magnesium (Mg++)
    • Chloride (Cl-)
    • Acetate (CH3COO-)
  • TotalNitrogenContent: 7.25 gm/L
  • TotalEnergyContent: 1551 kj/L (371.14 Kcal/L)

Pharmacology

  • Sterile aqueous solution of crystalline Amino Acid and D-Sorbitol with electrolytes
  • Clear, colorless to pale yellow colored solution
  • Positive nitrogen balance for postoperative period and extended periods of intravenous nutrition

Dosage & Administration

  • MaintenanceDose: 0.10-0.25 g nitrogen/kg/day
  • DosageRange: 15-35 ml Amino acids IV/kg/day
  • InfusionRate:
    • 1.4-2.8 ml (30-60 drops) per minute
    • 28-35 ml/kg body weight per day in children and infants

Interaction

No pharmacological effects and not expected to interact with other medicaments

Contraindications

  • Inborn errors of amino acids metabolism
  • Severe liver dysfunction
  • Severe uremia when dialysis facilities are not available
  • Hyperosmolar nonketotic diabetic coma

Side Effects

  • Nausea, vomiting, flushing, sweating
  • Transient increases in liver test
  • Hypersensitivity reactions
  • Thrombophlebitis
  • Hyperphenylalaninemia in severely ill, premature infants

Pregnancy & Lactation

Reported as successfully and safely administered during pregnancy

Precautions & Warnings

  • Increased urinary excretion of trace elements
  • Monitoring of phenylalanine levels in premature infants
  • Caution in patients with diabetes mellitus, severe heart failure, renal function, hyperglycemia, severe malnutrition, hypophosphatemia

Overdose Effects

  • Nausea, vomiting, sweating
  • Thrombophlebitis
  • Osmotic diuresis with dehydration
  • Risk of hyperglycemia symptoms

Therapeutic Class

Parenteral nutritional preparations

Storage Conditions

  • Store between 15°C to 25°C
  • Protect from light
  • Avoid freezing
  • Keep out of reach of children

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