Dextran 10%+5% (IV Infusion)

Indications

• Thromboembolic disorders
• Hypovolaemic shock
• Pulmonary embolism
• Venous thrombosis

Pharmacology

• Plasma volume expansion
• Blood viscosity reduction
• Inhibition of sludging or aggregation of red blood cells
• Source of calories and water for hydration
• Reduction of loss of body protein and nitrogen
• Promotion of glycogen deposition in the liver
• Stimulation of potassium uptake by cells with insulin

Dosage

• Adult IV Hypovolaemic shock: 10 mL/kg/day for up to 5 days
• Prophylaxis of post-op thromboembolic disorders: 500 ml during or at the end of surgery. May repeat dose next day and continue treatment on alternate days for up to 10 days in high-risk patients
• Child: Up to 5 ml/kg in infants and 10 ml/kg in children

Administration

• Contraindicated in hypersensitivity, severe renal disease with oliguria or anuria, marked cardiac decompensation, pregnancy

Interaction

• Interaction with enzyme inducers (e.g. phenytoin or carbamazepine)
• Interaction with enzyme inhibitors (e.g. cimetidine)

Side Effects

• Congestive heart failure
• Mild hypotension
• Tightness of chest
• Thrombocytopenia
• Anaphylaxis
• Injection site infection/phlebitis
• Acute renal failure
• Acidosis (if NaCI soln used)
• Pulmonary edema
• Wheezing

Pregnancy & Lactation

Pregnancy Category - C. Caution should be taken during pregnancy.

Precautions & Warnings

Caution should be taken during pregnancy

Therapeutic Class

Plasma expanders

Related Brands

• Dextran 6%+5% (IV Infusion) - institute-of-public-health-iph