Endoxan 200 mg/vial (IV Infusion)
200 mg vial: ৳ 222.63
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyclophosphamide |
| Company | Baxter |
| Also available as |
Indications
- Malignant lymphomas treatment
- Hodgkin's disease treatment
- Leukemias treatment
- Neuroblastoma treatment
- Ovarian adenocarcinoma treatment
- Retinoblastoma treatment
- Breast carcinoma treatment
- Nephrotic syndrome treatment
Pharmacology
- Liver biotransformation of cyclophosphamide
- Alkylating metabolites interference with cell growth
- Mechanism of DNA cross-linking
- Bioavailability after oral administration
- Elimination half-life
- Plasma protein binding
- Metabolites excretion in urine
Dosage & Administration
- Intravenous and oral dosing for malignant diseases
- Leukocyte count as dosage guide
- Dosage adjustment in combined cytotoxic regimens
- Dialyzable nature of cyclophosphamide and its metabolites
- Renal function impact on pharmacokinetic parameters
- Oral dosing in minimal change nephrotic syndrome
- Adrenocorticosteroid therapy tapering during cyclophosphamide therapy
Interaction
- Metabolism and leukopenic activity modulation by phenobarbital
- Alert for combined drug actions
- Potentiation of succinylcholine chloride effect by Endoxan
- Anesthesia caution within 10 days of Endoxan treatment
Contraindications
- Severely depressed bone marrow function
- Hypersensitivity
Side Effects
- Nausea and vomiting
- Anorexia
- Abdominal discomfort
- Hemorrhagic colitis
- Alopecia
- Skin rash
- Leukopenia
- Neutropenia
- Thrombocytopenia
- Hematuria
- Interstitial pneumonitis
- Anaphylactic reactions
- SIADH
- Malaise and asthenia
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in breast milk
- Consideration for nursing discontinuation
Precautions & Warnings
- Leukopenia
- Thrombocytopenia
- Tumor cell infiltration of bone marrow
- Impaired hepatic function
- Impaired renal function
Use in Special Populations
- Pediatric use safety profile
- Insufficient geriatric data
- Elderly patient cautious dose selection
Overdose Effects
- No specific antidote
- Supportive measures management
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Temperature and moisture storage instructions