Endoxan 500 mg/vial (IV Infusion)
500 mg vial: ৳ 521.76
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyclophosphamide |
| Company | Baxter |
| Also available as |
Indications
- Malignant lymphomas
- Hodgkin's disease
- Leukemias
- Mycosis fungoides
- Neuroblastoma
- Adenocarcinoma of the ovary
- Retinoblastoma
- Carcinoma of the breast
Pharmacology
- Liver biotransformation
- Active alkylating metabolites
- DNA cross-linking
- Good bioavailability
- Low plasma protein binding
Dosage & Administration
- Intravenous and oral dosing
- Adjustable dosages based on leukocyte count
- Dialyzable
- No consistent evidence for renal function dosage modification
Interaction
- Increased metabolism with phenobarbital
- Concurrent drug actions
- Potentiation of succinylcholine chloride effect
Contraindications
- Severely depressed bone marrow function
- Previous hypersensitivity
Side Effects
- Nausea and vomiting
- Anorexia
- Alopecia
- Leukopenia
- Hemorrhagic ureteritis
- Interstitial pneumonitis
- SIADH
Pregnancy & Lactation
- Category D
- Excreted in breast milk
- Potential for tumorigenicity
Precautions & Warnings
- Leukopenia
- Thrombocytopenia
- Impaired hepatic function
- Impaired renal function
Use in Special Populations
- Similar safety profile in pediatric patients
- Elderly patients may be more susceptible to toxicities
Overdose Effects
- No specific antidote
- Supportive measures for myelosuppression or cardiac toxicity
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Temperature not exceeding 25°C
- Dry place
- Protect from light and moisture
- Do not freeze