Endoxan 50 mg (Tablet)

Unit Price: ৳ 34.36 (5 x 10: ৳ 1,718.00)
Strip Price: ৳ 343.60

Medicine Details

Category Details
Generic Cyclophosphamide
Company Baxter
Also available as
Endoxan 200 mg injection Endoxan 500 mg injection Endoxan 1 gm injection

Indications

  • Malignant lymphomas treatment
  • Hodgkin’s disease treatment
  • Lymphocytic lymphoma treatment
  • Mixed-cell type lymphoma treatment
  • Histiocytic lymphoma treatment
  • Burkitt’s lymphoma treatment
  • Multiple myeloma treatment
  • Leukemias treatment
  • Mycosis fungoides treatment
  • Neuroblastoma treatment
  • Adenocarcinoma of the ovary treatment
  • Retinoblastoma treatment
  • Carcinoma of the breast treatment
  • Minimal Change Nephrotic Syndrome in Children treatment
  • Renal disease treatment

Pharmacology

  • Liver biotransformation
  • Active alkylating metabolites
  • Interference with growth of malignant cells
  • Cross-linking of tumor cell DNA
  • Oral administration
  • High bioavailability
  • Elimination half-life
  • Metabolism in urine

Dosage & Administration

  • Initial course dose
  • Intravenous dosing
  • Oral dosing
  • Intravenous regimens
  • Leukocyte count as dosage guide
  • Dialyzable
  • Renal function impact on dosage

Interaction

  • Metabolism rate impact
  • Leukopenic activity impact
  • Potential drug interactions
  • Cholinesterase activity inhibition
  • Inhibition of succinylcholine chloride

Contraindications

  • Severely depressed bone marrow function
  • Previous hypersensitivity

Side Effects

  • Nausea and vomiting
  • Anorexia
  • Abdominal discomfort
  • Hemorrhagic colitis
  • Oral mucosal ulceration
  • Alopecia
  • Skin rash
  • Leukopenia
  • Thrombocytopenia
  • Hemorrhagic ureteritis
  • Renal tubular necrosis
  • Interstitial pneumonitis
  • Anaphylactic reactions
  • Syndrome of inappropriate ADH secretion
  • Malaise and asthenia

Pregnancy & Lactation

  • Pregnancy Category D
  • Excretion in breast milk
  • Potential for serious adverse reactions
  • Tumorigenicity potential
  • Nursing decision

Precautions & Warnings

  • Leukopenia
  • Thrombocytopenia
  • Tumor cell infiltration of bone marrow
  • Previous X-ray therapy
  • Impaired hepatic function
  • Impaired renal function

Use in Special Populations

  • Pediatric use
  • Geriatric use

Overdose Effects

  • Supportive measures
  • Concurrent infection treatment
  • Myelosuppression treatment
  • Cardiac toxicity treatment

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Temperature storage
  • Protection from light and moisture
  • Avoid freezing

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