Endoxan 50 mg (Tablet)
Unit Price: ৳ 34.36 (5 x 10: ৳ 1,718.00)
Strip Price: ৳ 343.60
Medicine Details
Category | Details |
---|---|
Generic | Cyclophosphamide |
Company | Baxter |
Also available as |
Indications
- Malignant lymphomas treatment
- Hodgkin’s disease treatment
- Lymphocytic lymphoma treatment
- Mixed-cell type lymphoma treatment
- Histiocytic lymphoma treatment
- Burkitt’s lymphoma treatment
- Multiple myeloma treatment
- Leukemias treatment
- Mycosis fungoides treatment
- Neuroblastoma treatment
- Adenocarcinoma of the ovary treatment
- Retinoblastoma treatment
- Carcinoma of the breast treatment
- Minimal Change Nephrotic Syndrome in Children treatment
- Renal disease treatment
Pharmacology
- Liver biotransformation
- Active alkylating metabolites
- Interference with growth of malignant cells
- Cross-linking of tumor cell DNA
- Oral administration
- High bioavailability
- Elimination half-life
- Metabolism in urine
Dosage & Administration
- Initial course dose
- Intravenous dosing
- Oral dosing
- Intravenous regimens
- Leukocyte count as dosage guide
- Dialyzable
- Renal function impact on dosage
Interaction
- Metabolism rate impact
- Leukopenic activity impact
- Potential drug interactions
- Cholinesterase activity inhibition
- Inhibition of succinylcholine chloride
Contraindications
- Severely depressed bone marrow function
- Previous hypersensitivity
Side Effects
- Nausea and vomiting
- Anorexia
- Abdominal discomfort
- Hemorrhagic colitis
- Oral mucosal ulceration
- Alopecia
- Skin rash
- Leukopenia
- Thrombocytopenia
- Hemorrhagic ureteritis
- Renal tubular necrosis
- Interstitial pneumonitis
- Anaphylactic reactions
- Syndrome of inappropriate ADH secretion
- Malaise and asthenia
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in breast milk
- Potential for serious adverse reactions
- Tumorigenicity potential
- Nursing decision
Precautions & Warnings
- Leukopenia
- Thrombocytopenia
- Tumor cell infiltration of bone marrow
- Previous X-ray therapy
- Impaired hepatic function
- Impaired renal function
Use in Special Populations
- Pediatric use
- Geriatric use
Overdose Effects
- Supportive measures
- Concurrent infection treatment
- Myelosuppression treatment
- Cardiac toxicity treatment
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Temperature storage
- Protection from light and moisture
- Avoid freezing
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