Cyclotox 1 gm/vial (IV Infusion)

1 gm vial: ৳ 650.00

Medicine Details

Category	Details
Generic	Cyclophosphamide
Company	Beacon pharmaceuticals plc
Also available as	Cyclotox 200 mg injection

Indications

Malignant lymphomas treatment
Hodgkin's disease treatment
Leukemias treatment
Mycosis fungoides treatment
Retinoblastoma treatment
Carcinoma of the breast treatment
Minimal Change Nephrotic Syndrome treatment

Pharmacology

Biotransformation in the liver
Active alkylating metabolites
Interference with cell growth
Cross-linking of tumor cell DNA
High bioavailability
Elimination half-life
Plasma protein binding

Dosage & Administration

Intravenous and oral dosing
Initial course dosage
Leukocyte count as dosage guide
Adjusting dosages based on antitumor activity
Dialyzable metabolites
Dosage adjustments for compromised renal function

Interaction

Metabolism rate and leukopenic activity
Increased by phenobarbital
Alertness for combined drug actions
Potentiation of succinylcholine chloride effect

Contraindications

Severely depressed bone marrow function
Previous hypersensitivity

Side Effects

Nausea and vomiting
Anorexia
Hemorrhagic colitis
Alopecia
Skin rash
Leukopenia
Thrombocytopenia
Hemorrhagic ureteritis
Interstitial pneumonitis
Anaphylactic reactions
SIADH
Malaise and asthenia

Pregnancy & Lactation

Pregnancy Category D
Excretion in breast milk

Precautions & Warnings

Special attention in certain conditions
Leukopenia
Thrombocytopenia
Impaired hepatic function
Impaired renal function

Use in Special Populations

Pediatric use safety profile
Insufficient data for geriatric use

Overdose Effects

No specific antidote
Supportive measures for overdosage

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Temperature and moisture considerations

Related Brands