Cyclotox 1 gm/vial (IV Infusion)
1 gm vial: ৳ 650.00
Medicine Details
Category | Details |
---|---|
Generic | Cyclophosphamide |
Company | Beacon pharmaceuticals plc |
Also available as |
Indications
- Malignant lymphomas treatment
- Hodgkin's disease treatment
- Leukemias treatment
- Mycosis fungoides treatment
- Retinoblastoma treatment
- Carcinoma of the breast treatment
- Minimal Change Nephrotic Syndrome treatment
Pharmacology
- Biotransformation in the liver
- Active alkylating metabolites
- Interference with cell growth
- Cross-linking of tumor cell DNA
- High bioavailability
- Elimination half-life
- Plasma protein binding
Dosage & Administration
- Intravenous and oral dosing
- Initial course dosage
- Leukocyte count as dosage guide
- Adjusting dosages based on antitumor activity
- Dialyzable metabolites
- Dosage adjustments for compromised renal function
Interaction
- Metabolism rate and leukopenic activity
- Increased by phenobarbital
- Alertness for combined drug actions
- Potentiation of succinylcholine chloride effect
Contraindications
- Severely depressed bone marrow function
- Previous hypersensitivity
Side Effects
- Nausea and vomiting
- Anorexia
- Hemorrhagic colitis
- Alopecia
- Skin rash
- Leukopenia
- Thrombocytopenia
- Hemorrhagic ureteritis
- Interstitial pneumonitis
- Anaphylactic reactions
- SIADH
- Malaise and asthenia
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in breast milk
Precautions & Warnings
- Special attention in certain conditions
- Leukopenia
- Thrombocytopenia
- Impaired hepatic function
- Impaired renal function
Use in Special Populations
- Pediatric use safety profile
- Insufficient data for geriatric use
Overdose Effects
- No specific antidote
- Supportive measures for overdosage
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Temperature and moisture considerations
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