Cyclotox 200 mg/vial (IV Infusion)

200 mg vial: ৳ 180.00

Medicine Details

Category	Details
Generic	Cyclophosphamide
Company	Beacon pharmaceuticals plc
Also available as	Cyclotox 1 gm injection

Indications

Malignant lymphomas treatment
Hodgkin's disease treatment
Leukemias treatment
Neuroblastoma treatment
Adenocarcinoma of the ovary treatment
Retinoblastoma treatment
Carcinoma of the breast treatment
Minimal Change Nephrotic Syndrome treatment
Nonmalignant Disease treatment

Pharmacology

Biotransformation in the liver
Interference with growth of malignant cells
Mechanism of action involves cross-linking of tumor cell DNA
High oral bioavailability

Dosage & Administration

Intravenous administration
Oral administration
Dosage adjustment based on leukocyte count
Dialyzable
No consistent evidence for dosage modification in renal impairment

Interaction

Increased metabolism and leukopenic activity with phenobarbital
Possible combined drug actions
Potentiation of succinylcholine chloride effect

Contraindications

Severely depressed bone marrow function
Previous hypersensitivity

Side Effects

Nausea and vomiting
Anorexia
Alopecia
Skin rash
Leukopenia
Hemorrhagic ureteritis
Renal tubular necrosis
Interstitial pneumonitis
Thrombocytopenia
Anemia
Malaise and asthenia

Pregnancy & Lactation

Pregnancy Category D
Excretion in breast milk

Precautions & Warnings

Special attention in patients with certain conditions
Impaired hepatic function
Impaired renal function

Use in Special Populations

Pediatric use safety profile similar to adults
Elderly patients may be more susceptible to toxicities

Overdose Effects

No specific antidote known
Supportive measures management

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Temperature not exceeding 25°C, protect from light and moisture, do not freeze

Related Brands