Mesna 400 mg/4 ml (IV Injection)
400 mg vial: ৳ 190.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Mesna |
| Company | Techno drugs ltd |
Indications
- Prophylactic agent for ifosfamide-induced hemorrhagic cystitis
- Prevention of high dose cyclophosphamide-induced hemorrhagic cystitis
Pharmacology
- Rapid oxidation to Mesna disulfide
- Elimination by the kidneys
- Detoxification of urotoxic ifosfamide metabolites
Dosage & Administration
- Intravenous bolus injections for prophylaxis
- Preparation of intravenous solutions
- Fractionated dosing schedule
Interaction
- No clinical drug interaction studies conducted
Contraindications
- Hypersensitivity to Mesna or excipients
Side Effects
- Colic
- Depression
- Diarrhea
- Fatigue
- Headache
- Hypotension
- Irritability
- Joint pains
- Nausea
- Rash
- Tachycardia
- Vomiting
Pregnancy & Lactation
- Pregnancy Category B
- No adequate and well-controlled studies in pregnant women
- Uncertain excretion in human milk
Precautions & Warnings
- Allergic reactions
- Higher incidence in patients with autoimmune disorders
- Limited effectiveness in preventing hemorrhagic cystitis in all patients
- Examination of urine for hematuria
- Risk reduction measures for hematuria
- Use caution in pediatric patients
Overdose Effects
- No known antidote
- Lethal oral doses in animal studies
Therapeutic Class
- Antidote preparations
Storage Conditions
- Store in original carton at 20°C-25°C
- Protect from light
- Keep out of the reach of children