Uromitexan 400 mg/4 ml (IV Injection)
400 mg vial: ৳ 215.61 (3 x 5: ৳ 3,234.15)
Medicine Details
Indications
- Prophylactic agent for ifosfamide-induced hemorrhagic cystitis
- Prevention of high dose cyclophosphamide-induced hemorrhagic cystitis
Pharmacology
- Rapid oxidation to Mesna disulfide
- Rapid elimination by the kidneys
- Reduction to free thiol compound Mesna
- Chemical reaction with urotoxic ifosfamide metabolites
- Detoxification of acrolein and 4-hydroxy-ifosfamide
Dosage & Administration
- Fractionated dosing schedule
- Intravenous bolus injection at 20% of ifosfamide dosage
- Intravenous administration at 4 and 8 hours after each dose of ifosfamide
- Total daily dose of Mesna is 60% of ifosfamide dose
- Preparation of intravenous solutions in various fluids
Interaction
- No clinical drug interaction studies conducted
Contraindications
- Known hypersensitivity to Mesna or any excipients
Side Effects
- Colic
- Depression
- Diarrhea
- Fatigue
- Headache
- Hypotension
- Irritability
- Joint pains
- Limb pains
- Nausea
- Rash
- Tachycardia
- Vomiting
Pregnancy & Lactation
- Pregnancy Category B
- No adequate and well-controlled studies in pregnant women
- Unknown excretion in human milk
Precautions & Warnings
- Reports of allergic reactions, including anaphylactic reactions
- Higher incidence in patients with autoimmune disorders
- May not prevent or alleviate other adverse reactions of ifosfamide therapy
- Requirement of daily urine examination for hematuria
- Not effective in reducing the risk of hematuria due to other conditions
- Benzyl alcohol content caution for pediatric use
Overdose Effects
- No known antidote
- Lethal oral doses in mice and rats
Therapeutic Class
- Antidote preparations
Storage Conditions
- Store in original carton at 20°-25°C
- Protect from light
- Keep out of the reach of children