Xeloda 500 mg (Tablet)
Unit Price: ৳ 220.74 (12 x 10: ৳ 26,488.80)
Strip Price: ৳ 2,207.40
Medicine Details
| Category | Details |
|---|---|
| Generic | Capecitabine |
| Company | Roche bangladesh ltd |
Title and Categories
- Xeloda
- Cancer treatment
- Chemotherapy
- Antineoplastic agent
- Oral chemotherapy
- Fluoropyrimidine therapy
Dosage and Administration
- Recommended dose of 1250 mg/m2 twice daily
- Orally administered
- Cycles of 2 weeks on and 1 week off
- Dose adjustment for patients with moderate renal impairment
- Individualized dosage based on patient's body surface area
Indications
- Adjuvant Colon Cancer
- Metastatic Colorectal Cancer
- Metastatic Breast Cancer
- Treatment resistant to paclitaxel and anthracycline-containing regimen
- First-line monotherapy for certain cancers
Pharmacology
- Prodrug enzymatically converted to fluorouracil
- Inhibition of DNA synthesis
- Slowing of tumor tissue growth
- Selective tumor-activated cytotoxic moiety
Interactions
- Anticoagulants
- Phenytoin
- Leucovorin
- CYP2C9 substrates
- Food intake reducing absorption
Contraindications
- Severe Renal Impairment
- Hypersensitivity
- Blood cell deficiencies
- Reactions to fluoropyrimidine therapy
- Complete DPD deficiency
- Pregnancy or breastfeeding
Side Effects
- Abdominal pain
- Rash
- Dry or itchy skin
- Tiredness
- Loss of appetite
- Diarrhea
- Vomiting
- Nausea
- Stomatitis
- Hand-and-foot skin-reaction
- Fever
- Infection
- Chest pain
- Steven-Johnson syndrome
Pregnancy and Lactation
- Pregnancy category D
- Potential fetal harm
- Advice to discontinue breastfeeding during treatment and 2 weeks after final dose
Precautions and Warnings
- Coagulopathy monitoring
- Diarrhea management
- Cardiotoxicity risk
- Increased risk in low DPD activity patients
- Dehydration and renal failure precautions
- Mucocutaneous and dermatologic toxicity management
- Hyperbilirubinemia monitoring
- Hematologic parameters to be considered
Overdose Effects
- Manifestations including nausea, vomiting, diarrhea
- Gastrointestinal irritation and bleeding
- Bone marrow depression
- Customary therapeutic and supportive medical interventions
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Keep in a dry place
- Store below 30°C
- Protection from light
- Keep out of the reach of children