Gemoxen 200 mg/vial (IV Infusion)

200 mg vial: ৳ 1,600.00

Medicine Details

Category Details
Generic Gemcitabine
Company Beacon pharmaceuticals plc
Also available as
Gemoxen 1 gm injection

Indications

  • Non-Small Cell Lung Cancer
  • Pancreatic Cancer
  • Bladder Cancer
  • Breast Cancer
  • Ovarian Cancer

Pharmacology

  • Metabolized intracellularly by nucleoside kinases
  • Cytotoxic action due to inhibition of DNA synthesis
  • Inhibition of ribonucleotide reductase
  • Competes with dCTP for incorporation into DNA
  • Induces programmed cellular death process

Dosage & Administration

  • Recommended dose of Gemcitabine is 1000 mg/m2
  • Given by 30-minute intravenous infusion
  • Dosage reduction based on toxicity
  • Dosing regimens for different types of cancer

Interaction

  • No confirmed interactions reported
  • No specific drug interaction studies conducted

Contraindications

  • Contraindicated in patients with hypersensitivity to Gemcitabine or any components

Side Effects

  • Haematological Toxicity
  • Hepatic Toxicity
  • Gastrointestinal
  • Genito-Urinary Toxicity
  • Pulmonary Toxicity
  • Allergic Toxicity
  • Neurotoxicity
  • Alopecia

Pregnancy & Lactation

  • Pregnancy Category D
  • Use during pregnancy
  • Unknown excretion in human breast milk

Precautions & Warnings

  • Caution needed for various toxicities and risks
  • Exercise caution in patients with specific risks

Use in Special Populations

  • Elderly Patients
  • Renal and Hepatic Impairment
  • Caution needed in children

Overdose Effects

  • No known antidote for overdoses
  • Principal toxicities seen with high doses
  • Monitoring and supportive therapy recommended

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store in original carton at 20°C to 25°C
  • Away from light
  • Do not refrigerate to avoid crystallisation
  • Keep out of reach of children

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