Methotrax 10 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Delta pharma ltd |
| Also available as |
Title
Methotrexate Medicine
Categories
- Chemotherapy
- Immunosuppressant
- Antidote preparations
Description
Methotrexate is used for the treatment of neoplastic diseases such as gestational choriocarcinoma, chorioadenoma destruens, hydatidiform mole, acute lymphoblastic leukemia, non-Hodgkin's lymphomas, breast cancer, head and neck cancer, psoriasis, rheumatoid arthritis, and polyarticular-course juvenile rheumatoid arthritis.
Color Options
- Not applicable
Dimensions
- Not applicable
Material
- Not applicable
Technical Specifications
- Inhibits dihydrofolic acid reductase
- Interferes with DNA synthesis and cellular replication
Design Elements
- Antidote preparations
- Immunosuppressant
Usability Features
- Oral and intramuscular administration
Dosage
- 15 to 30 mg daily for a five-day course for choriocarcinoma and similar trophoblastic diseases
- 3.3 mg/m2 induction dose in acute lymphoblastic leukemia
- 40 mg/m2 intravenously for breast cancer
- 7.5 mg once per week for adult rheumatoid arthritis
- 10 mg/m2 weekly for polyarticular-course juvenile rheumatoid arthritis
- 10 to 25 mg once per week for psoriasis
Administration
- Should be taken on an empty stomach
- May be taken with meals to reduce GI discomfort
- Avoid taking with milk-rich products
Interaction
- Should not be administered with high doses of Methotrexate
- Toxicity may be increased with certain drugs
- Should be closely monitored for possible increased risk of hepatotoxicity with Sulfasalazine
Contraindications
- Alcoholism or alcoholic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnant women with psoriasis or rheumatoid arthritis
- Nursing mothers
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea
- Malaise
- Fatigue
- Dizziness
- Decreased resistance to infection
- Impairment of fertility, oligospermia, menstrual dysfunction
Pregnancy & Lactation
- US FDA Pregnancy Category X
- Contraindicated in nursing mothers
Precautions & Warnings
- Methotrex formulations and diluents containing preservatives must not be used for intrathecal or high dose therapy
- Necessary to follow patients closely for toxic effects
- Persistent liver function test abnormalities may indicate serious liver toxicity
- Folate deficiency may increase Methotrex toxicity
Use in Special Populations
- Benefits vs risk should be weighed in pediatric patients
- Elderly patients should be closely monitored for toxicity
Overdose Effects
- Leucovorin is indicated to diminish the toxicity and counteract the effect of overdosages
Therapeutic Class
- Antidote preparations
- Immunosuppressant
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protect from light & moisture