Methox 10 mg (Tablet)

Unit Price: ৳ 15.06 (3 x 10: ৳ 451.80)

Strip Price: ৳ 150.60

Medicine Details

Category	Details
Generic	Methotrexate
Company	Popular pharmaceuticals ltd
Also available as	Methox 25 mg tablet

Indications

Treatment of gestational choriocarcinoma
Chorioadenoma destruens and hydatidiform mole
Acute lymphoblastic leukemia
Non-Hodgkin’s lymphomas
Breast cancer
Epidermoid cancers of the head and neck
Mycosis fungoides
Lung cancer (squamous cell and small cell types)
Rheumatoid arthritis
Polyarticular-course juvenile rheumatoid arthritis
Psoriasis
Symptomatic control of severe, recalcitrant, disabling psoriasis

Pharmacology

Inhibits dihydrofolic acid reductase, interferes with DNA synthesis, repair, and cellular replication

Dosage

Doses for various neoplastic diseases, leukemia, lymphoma, mycosis fungoides, breast cancer, head and neck cancer, rheumatoid arthritis, juvenile rheumatoid arthritis, and psoriasis

Administration

Should be taken on an empty stomach, may be taken with meals to reduce GI discomfort, avoid taking with milk-rich products

Interaction

Interaction with NSAIDs, salicylates, phenylbutazone, phenytoin, sulfonamides, cisplatin, mercaptopurine, tetracycline, chloramphenicol, nonabsorbable broad spectrum antibiotics, vitamin preparations containing folic acid or its derivatives, trimethoprim/sulfamethoxazole

Contraindications

Alcoholism or alcoholic liver disease
Chronic liver disease
Immunodeficiency syndromes
Pre-existing blood dyscrasias
Hypersensitivity to methotrexate
Pregnant women with psoriasis or rheumatoid arthritis
Women of childbearing potential
Nursing mothers

Side Effects

Ulcerative stomatitis
Leukopenia
Nausea
Abdominal distress
Malaise
Fatigue
Chills
Fever
Dizziness
Decreased resistance to infection
Impairment of fertility
Oligospermia
Menstrual dysfunction

Pregnancy & Lactation

US FDA Pregnancy Category X, contraindicated in nursing mothers

Precautions & Warnings

Formulations and diluents containing preservatives must not be used for intrathecal or high dose therapy
Necessary to closely follow patients for toxic effects
If adverse reactions occur, reduce dosage or discontinue
Consideration for the use of leucovorin calcium if necessary
Increased alertness as to possible recurrence of toxicity
Evaluation of persistent liver function test abnormalities
Consideration of possible folate deficiency

Use in Special Populations

Pediatric patients: Benefits vs. potential risk
Geriatric patients: Monitor for signs of hepatic, bone marrow, and renal toxicity

Overdose Effects

Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages