Mtrex 50 mg/2 ml (IV Injection or Infusion)
50 mg vial: ৳ 110.00 (1 x 5: ৳ 550.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Techno drugs ltd |
| Also available as |
Indications
- Treatment of gestational choriocarcinoma
- Treatment of chorioadenoma destruens
- Treatment of hydatidiform mole
- Treatment of acute lymphoblastic leukemia
- Treatment of non-Hodgkin’s lymphomas
- Treatment of breast cancer
- Treatment of head and neck cancer
- Treatment of mycosis fungoides
- Treatment of lung cancer
- Management of severe, active rheumatoid arthritis
- Management of polyarticular-course juvenile rheumatoid arthritis
- Symptomatic control of severe, recalcitrant, disabling psoriasis
Pharmacology
- Inhibition of dihydrofolic acid reductase
- Interference with DNA synthesis
- Interference with repair and cellular replication
- Sensitivity in malignant cells
- Increased production of epithelial cells in psoriasis
Dosage
- Oral or intramuscular administration
- Varied doses for different diseases
- Induction and maintenance doses
- Intravenous administration for breast cancer
- Adult rheumatoid arthritis dose
- Juvenile rheumatoid arthritis dose
- Psoriasis dose
Administration
- Should be taken on an empty stomach
- May be taken with meals to reduce GI discomfort
- Avoid taking with milk-rich products
Interaction
- Interaction with NSAIDs
- Increased toxicity with salicylates, phenylbutazone, phenytoin, and sulfonamides
- Increased risk of hepatotoxicity with sulfasalazine
- Cautious use with cisplatin and mercaptopurine
- Decreased intestinal absorption with tetracycline and chloramphenicol
- Decreased response with folic acid or its derivatives
- Rare bone marrow suppression with trimethoprim/sulfamethoxazole
Contraindications
- Alcoholism or alcoholic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnant women with psoriasis or rheumatoid arthritis
- Women of childbearing potential
- Nursing mothers
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea and abdominal distress
- Malaise
- Fatigue
- Chills and fever
- Impairment of fertility
- Oligospermia
- Menstrual dysfunction
Pregnancy & Lactation
- US FDA Pregnancy Category X
- Contraindicated in nursing mothers
Precautions & Warnings
- Avoid intrathecal or high dose Mtrex therapy
- Close monitoring for toxic effects
- Reduced dosage or discontinuation on adverse reactions
- Reinstitute therapy with caution
- Evaluation for liver toxicity
- Consideration of folate deficiency
Use in Special Populations
- Benefits outweighing potential risk in pediatric patients
- Monitoring for toxicity in elderly patients
Overdose Effects
- Indicated use of leucovorin to diminish toxicity
Therapeutic Class
- Antidote preparations
- Immunosuppressant
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light and moisture