Trexonate 2.5 mg (Tablet)

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Methotrexate
Company Beacon pharmaceuticals plc
Also available as
Trexonate 10 mg tablet Trexonate 50 mg injection

Indications

  • Treatment of gestational choriocarcinoma, chorioadenoma destruens, and hydatidiform mole
  • Management of selected adults with severe, active rheumatoid arthritis
  • Symptomatic control of severe, recalcitrant, disabling psoriasis
  • Treatment of acute lymphoblastic leukemia
  • Used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin’s lymphomas
  • Treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides, and lung cancer
  • Indicated in the management of children with active polyarticular-course juvenile rheumatoid arthritis

Pharmacology

  • Inhibits dihydrofolic acid reductase
  • Interferes with DNA synthesis, repair, and cellular replication
  • Impairs malignant growth without irreversible damage to normal tissues
  • Controls the psoriatic process

Dosage

  • Orally or intramuscularly in doses of 15 to 30 mg daily for a five-day course
  • Induction dose of 3.3 mg/m2 in combination with prednisone for 4 to 6 weeks
  • Maintenance dose of 30 mg/m2 weekly
  • 40 mg/m2 intravenously on the 1st and 8th day every 4 weeks in combination with other drugs
  • Single doses of 7.5 mg once per week for adult rheumatoid arthritis

Administration

  • Should be taken on an empty stomach
  • May be taken with meals to reduce gastrointestinal discomfort
  • Avoid taking with milk-rich products

Interaction

  • Should not be administered prior to or concomitantly with high doses of Trexonate
  • Toxicity may be increased with salicylates, phenylbutazone, phenytoin, and sulfonamides
  • Should be closely monitored for possible increased risk of hepatotoxicity when used concomitantly with sulfasalazine
  • Caution must be exercised if high-dose Trexonate is administered in combination with cisplatin
  • Increases the plasma levels of mercaptopurine
  • May decrease intestinal absorption when used concomitantly with tetracycline, chloramphenicol, and nonabsorbable broad spectrum antibiotics
  • Decreases responses to systemically administered Trexonate when used with vitamin preparations containing folic acid or its derivatives

Contraindications

  • Chronic liver disease
  • Immunodeficiency syndromes
  • Pre-existing blood dyscrasias
  • Hypersensitivity to methotrexate
  • Pregnancy and lactation
  • Nursing mothers

Side Effects

  • Ulcerative stomatitis
  • Leukopenia
  • Nausea and abdominal distress
  • Malaise and undue fatigue
  • Chills and fever
  • Dizziness and decreased resistance to infection
  • Impairment of fertility, oligospermia, and menstrual dysfunction

Pregnancy & Lactation

  • US FDA Pregnancy Category X
  • Contraindicated in nursing mothers

Precautions & Warnings

  • Trexonate formulations and diluents containing preservatives must not be used for intrathecal or high dose therapy
  • Necessary to follow patients closely for toxic effects
  • Persistent liver function test abnormalities may indicate serious liver toxicity

Use in Special Populations

  • Benefits should be weighed against the potential risk before using Trexonate in pediatric patients or young adults
  • Elderly patients should be closely monitored for early signs of toxicity

Overdose Effects

  • Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages

Therapeutic Class

  • Antidote preparations
  • Immunosuppressant

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture

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