Trexonate 50 mg/2 ml (IV Injection or Infusion)
50 mg vial: ৳ 130.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole
- Used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin’s lymphomas
- In acute lymphoblastic leukemia
- Treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T-cell lymphoma) and lung cancer
- Management of selected adults with severe, active rheumatoid arthritis
- Symptomatic control of severe, recalcitrant, disabling psoriasis
Pharmacology
Methotrexate inhibits dihydrofolic acid reductase. Interferes with DNA synthesis, repair, and cellular replication. Actively proliferating tissues are more sensitive to this effect. Used to control the psoriatic process.
Dosage
- Orally or intramuscularly in doses of 15 to 30 mg for a five-day course for choriocarcinoma and similar trophoblastic diseases
- Induction dose: 3.3 mg/m2 in combination with prednisone 60 mg/m2 daily for 4 to 6 weeks in acute lymphoblastic leukemia
- Single doses of 7.5 mg once per week for adult rheumatoid arthritis
- 10 mg/m2 once weekly for polyarticular-course juvenile rheumatoid arthritis
- Single dose: 10 to 25 mg once per week for psoriasis
Administration
- Should be taken on an empty stomach
- May be taken with meals to reduce GI discomfort
- Avoid taking with milk-rich products
Interaction
- NSAIDs should not be administered prior to or concomitantly with high doses of Methotrexate
- Toxicity may be increased with Salicylates, Phenylbutazone, Phenytoin, and Sulfonamides
- Should be closely monitored for possible increased risk of hepatotoxicity when used with Sulfasalazine
- Caution must be exercised if high-dose Methotrexate is administered in combination with Cisplatin
- Methotrexate increases the plasma levels of Mercaptopurine
- May decrease intestinal absorption of Methotrexate when used with Tetracycline, Chloramphenicol, and Nonabsorbable Broad Spectrum Antibiotics
Contraindications
- Alcoholism, alcoholic liver disease or chronic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnant women with psoriasis or rheumatoid arthritis
- Nursing mothers
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea and abdominal distress
- Malaise and undue fatigue
- Impairment of fertility, oligospermia, and menstrual dysfunction
Pregnancy & Lactation
US FDA Pregnancy Category X. Methotrexate should be used in the treatment of neoplastic diseases only when the potential benefit outweighs the risk to the fetus. It is contraindicated in nursing mothers.
Precautions & Warnings
- Trexonate formulations and diluents containing preservatives must not be used for intrathecal or high dose Methotrexate therapy
- Necessary to follow patients on Methotrexate closely for toxic effects
- If adverse reactions occur, the drug should be reduced in dosage or discontinued and appropriate corrective measures should be taken
Use in Special Populations
- Benefits should be weighed against the potential risk before using Methotrexate in pediatric patients
- Elderly patients should be closely monitored for early signs of hepatic, bone marrow, and renal toxicity
Overdose Effects
Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages of Methotrexate
Therapeutic Class
Antidote preparations, Immunosuppressant
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture