MTX 2.5 mg (Tablet)
Unit Price: ৳ 5.40 (100's pack: ৳ 540.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Choongwae pharma corporation |
| Also available as |
Title
- Methotrexate Tablet
Categories
- Antineoplastic Agent
- Immunosuppressant
Indications
- Treatment of gestational choriocarcinoma
- Chorioadenoma destruens
- Hydatidiform mole
- Acute lymphoblastic leukemia
- Advanced stage non-Hodgkin's lymphomas
- Rheumatoid arthritis
- Polyarticular-course juvenile rheumatoid arthritis
- Psoriasis
Pharmacology
- Inhibition of dihydrofolic acid reductase
- Interference with DNA synthesis
- Repair and cellular replication
- Selective sensitivity to actively proliferating tissues
Dosage
- Oral or intramuscular administration
- Doses of 15 to 30 mg daily
- Induction and maintenance doses for different indications
- Intravenous administration for cancer treatment
Administration
- Best taken on an empty stomach
- May be taken with meals to reduce GI discomfort
- Avoid taking with milk-rich products
Interaction
- Avoid concomitant use with NSAIDs
- Potential increased toxicity with several medications
- Possible hepatotoxicity with sulfasalazine
- Increased plasma levels of mercaptopurine with methotrexate
Contraindications
- Alcoholism or alcoholic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnancy and nursing mothers
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea
- Abdominal distress
- Malaise
- Fatigue
- Chills
- Fever
- Impairment of fertility
Pregnancy & Lactation
- US FDA Pregnancy Category X
- Use only when potential benefit outweighs fetal risk
- Contradicted in nursing mothers
Precautions & Warnings
- Avoid use of MTX formulations and diluents containing preservatives for intrathecal or high-dose therapy
- Close monitoring for toxic effects
- Prompt action for adverse reactions
- Caution in reinstituting MTX therapy
- Evaluation of liver function indicators
- Consideration of folate deficiency
Use in Special Populations
- Caution in pediatric and young adult use
- Close monitoring in geriatric patients for hepatic, bone marrow, and renal toxicity
Overdose Effects
- Leucovorin administration for toxicity reduction
Therapeutic Class
- Antidote preparations
- Immunosuppressant
Storage Conditions
- Store at a temperature not exceeding 30°C
- Dry place
- Protect from light and moisture