MTX 50 mg/2 ml (IV Injection or Infusion)
50 mg vial: ৳ 130.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Choongwae pharma corporation |
| Also available as |
Indications
- Treatment of gestational choriocarcinoma
- Chorioadenoma destruens
- Hydatidiform mole
- Acute lymphoblastic leukemia
- Non-Hodgkin’s lymphomas
- Rheumatoid Arthritis
- Polyarticular-Course Juvenile Rheumatoid Arthritis
- Psoriasis
Pharmacology
Inhibition of dihydrofolic acid reductase
Dosage
- Oral or intramuscular administration
- Different dosage for different diseases
- Maintenance dose
- IV administration for breast and head & neck cancer
Administration
Should be taken on an empty stomach
Interaction
- Avoid high doses with NSAIDs
- Increased toxicity with certain drugs
- Hepatotoxicity risk with sulfasalazine
- Exercise caution with cisplatin
Contraindications
- Alcoholism or alcoholic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnant women with psoriasis or rheumatoid arthritis
- Nursing mothers
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea
- Malaise
- Fatigue
- Dizziness
Pregnancy & Lactation
FDA Pregnancy Category X. Contraindicated in nursing mothers
Precautions & Warnings
- Avoid use of MTX formulations with preservatives for intrathecal or high dose therapy
- Close monitoring for toxic effects
- Consider leucovorin calcium for adverse reactions
Use in Special Populations
- Consider benefits against risks in pediatric patients
- Close monitoring for elderly patients
Overdose Effects
Leucovorin is an antidote for MTX overdosages
Therapeutic Class
Antidote preparations, Immunosuppressant
Storage Conditions
Store at temperature not exceeding 30°C, protect from light & moisture