Biofol 15 mg (Tablet)
Unit Price: ৳ 25.00 (3 x 10: ৳ 750.00)
Strip Price: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists
- Minimizing systemic toxicity in calcium folinate rescue treatment
- Treating megaloblastic anaemias due to various causes
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Calcium salt of folinic acid
- Metabolite and active form of folic acid
- Cofactor for 1-carbon transfer reactions
- Involvement in biosynthesis of nucleic acids
- Antidote for hematopoietic and reticuloendothelial toxic effects
Dosage & Administration
- Recommended dose for calcium folinate rescue
- Dosing regimens based on the dose of methotrexate administered
- Dosing for neutralizing immediate toxic effects of folic acid antagonists
- Dosing for megaloblastic anemia (folate deficiency)
Interaction
- Counteracting antiepileptic effect of phenobarbitone, phenytoin, and primidone
- Increasing the frequency of seizures in susceptible patients when combined with fluoropyrimidine
Contraindications
- Known hypersensitivity to calcium folinate
- Pernicious anemia or other megaloblastic anemia with vitamin B12 deficiency
- Rare hereditary problems of galactose intolerance, lapp lactase deficiency, or glucose-galactose malabsorption
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Limited clinical studies in pregnant women
- Caution for use in nursing mothers
Precautions & Warnings
- Use only with methotrexate or 5-FU under supervision of experienced clinician
- Prompt administration in case of inadvertent overdosage
- Avoid giving simultaneously with folic acid antagonists
Overdose Effects
- Nullification of the chemotherapeutic effect of folic acid antagonists
- No specific antidote
- Appropriate supportive care
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children