Folinex 10 mg/ml (IM/IV Injection)
50 mg vial: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Title and Categories
- Calcium Folinate Tablet
- Supportive Care Therapy
Composition
- Each tablet contains Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Each tablet contains Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimize systemic toxicity
- The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease, and malabsorption syndrome
Pharmacology
- Calcium Folinate Hydrate is a calcium salt of folinic acid, involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of nucleic acids
Dosage and Administration
- Calcium folinate rescue treatment should commence approximately 24 hours after the beginning of methotrexate infusion
- Recommended dose of Folinic Acid to counteract hematologic toxicity from folic acid antagonists with less affinity for mammalian dihydrofolate reductase than methotrexate is substantially less and 5 mg to 15 mg per day has been recommended
Interaction
- Folinates given in large amounts may counteract the antiepileptic effect of phenobarbitone, phenytoin, and primidone
- Caution is required during concurrent administration with fluoropyrimidine as this has been associated with seizures and syncope
Contraindications
- Known hypersensitivity to calcium folinate or any other components of this product
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
- Rare hereditary problems of galactose intolerance, the lapp lactase deficiency, or glucose-galactose malabsorption
Side Effects
- Mucositis, stomatitis, leukopenia, and/or diarrhea
Pregnancy and Lactation
- Use in pregnant women if the potential benefit justifies the potential risk to the fetus
- Exercise caution when administered to a nursing mother due to potential excretion in human milk
Precautions and Warnings
- Should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- Calcium folinate should not be given simultaneously with folic acid antagonists, e.g. methotrexate, to abort clinical toxicity
Overdose Effects
- Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
Technical Specifications
- Tablet size: standard
- Available dosages: 5mg, 15mg
Design Elements
- Tablet shape: standard
- Tablet color: not specified
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children