Apedom 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 27.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Apollo pharmaceutical ltd |
| Also available as |
Title and Categories
- Domperidone 5 mg/5 ml Suspension
- Dopamine antagonist
- Motility Stimulants
- Prokinetic drugs
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- ChemoreceptorTrigger Zone (CTZ) blocker
- Gastroprokinetic action
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
Dosage and Administration
- Taken 15-30 minutes before meals
- Usual recommended oral dose for adults: 10-20 mg every 6-8 hours daily
- Usual recommended oral dose for children: 2-4 ml suspension/10 kg body weight every 6-8 hours daily
Interaction
- Anticholinergic drugs may antagonize the antidyspeptic effect
- Concomitant use of drugs that significantly inhibit CYP3A4 may result in increased plasma levels of domperidone
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Extrapyramidal phenomena
- Increase in plasma prolactin level
- Rare allergic reactions such as rash and urticaria
Pregnancy and Lactation
- Use during the first trimester if justified by therapeutic benefit
- Excreted in breast milk
- Concentrations in breast milk are 4 times lower than corresponding plasma concentrations
- Not recommended for nursing mothers unless expected benefits outweigh potential risk
Precautions and Warnings
- Absolute caution in the case of children
- Increased risk of extrapyramidal reactions in young children
- Use with caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to incomplete blood-brain barrier
- Use with caution in patients with hepatic impairment
- Reduction of dosing frequency in patients with severe renal insufficiency
Overdose Effects
- Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
- Recommendations for management in case of overdosage
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image
Commonly Asked Questions
- Uses of Apedom 5 mg/5 ml Suspension
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