Eposide 100 mg/5 ml (IV Infusion)
100 mg vial: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoposide |
| Company | Techno drugs ltd |
| Also available as |
Indications
- Small Cell Lung Cancer management
- First-line treatment
- Combination therapy
Pharmacology
- Pharmacotherapeutic classification: podophyllotoxin derivatives
- Mitosis inhibition
- Cell cycle progression inhibition
- Nucleic acid synthesis non-interference
- Biphasic disposition
- Distribution half-life
- Terminal elimination half-life
- Total body clearance
- Plasma concentration vs time curves (AUC)
- Maximum plasma concentration (Cmax)
- Volume of distribution at steady state
Dosage & Administration
- Dosage for small cell lung cancer
- Dose modification based on renal function
- Creatinine clearance-based dosing
Interaction
- Interaction with high-dose cyclosporine a
- Effect on Eposide exposure
- Laboratory tests requirement
Contraindications
- Hypersensitivity contraindication
Side Effects
- Myelosuppression
- Granulocyte nadirs
- Platelet nadirs
- Fever and infection risk
- Acute leukemia occurrence
- Nausea and vomiting
- Mild to severe mucositis/esophagitis
- Hypotension
- Allergic reactions - anaphylactic-like reactions
- Hypertension and flushing
- Alopecia
- Abdominal pain
- Constipation
- Fatigue
- Optic neuritis
Pregnancy & Lactation
- Pregnancy category D
- Excretion in human milk
- Breastfeeding precaution
Precautions & Warnings
- Myelosuppression monitoring
- Dose-limiting bone marrow suppression
- Anaphylactic reaction possibility
- Infusion-related reactions
- Hypotension risk
- Severe adverse reaction management
- Serum albumin influence
- Refrigeration storage requirement
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
- Refrigeration storage
- Stability duration under refrigeration
- Protection from light
- Proper handling and disposal procedure