Vinblastin 10 mg/10 ml (Injection)

Title

• Vinblastine Sulfate Injection

Categories

• Medicine
• Pharmaceuticals
• Chemotherapy

Description

• Vinblastine is an antineoplastic agent used in the treatment of Hodgkin’s disease, advanced testicular carcinoma, lymphocytic lymphoma, and other cancers.

Color Options

• Clear

Formulation

• Injection

Ingredients

• Vinblastine Sulfate

Package Size

• Single-Dose Vial

Route of Administration

• Intravenous

Therapeutic Class

• Cytotoxic Chemotherapy

Indications

• Treatment of Hodgkin’s disease
• Advanced testicular carcinoma
• Lymphocytic lymphoma
• Choriocarcinoma
• Breast carcinoma

Mode of Action

• Binds to microtubular proteins
• Arrests mitosis at metaphase
• Blocks glutamic acid utilization

Dosage & Administration

• Initial dose based on body surface area
• Incremental dose adjustments based on leukocyte count
• Usual dose range for adults and children
• Duration of maintenance therapy varies

Interaction

• Possible interactions with aprepitant, miconazole, phenytoin, vaccines, zidovudine, and CYP3A inhibitors

Contraindications

• Severe bone marrow suppression
• Bacterial infection
• Intramuscular injection into poorly perfused extremities
• Porphyria
• Pregnancy
• Lactation

Side Effects

• Alopecia
• Constipation
• Bone marrow suppression
• Hypertension
• Neurotoxicity
• Cardiac toxicity
• Nausea
• Vomiting
• GI bleed
• Cellulitis with extravasation

Pregnancy & Lactation

• Category D - Positive evidence of human fetal risk

Precautions & Warnings

• Hepatic impairment
• Neurotoxicity
• Ischemic heart disease
• Pulmonary dysfunction
• Extravasation management
• Constipation prophylaxis
• Leukocyte count nadir and recovery

Use in Special Populations

• Dosage adjustment for hepatic impairment

Overdose Effects

• Severe bone marrow suppression
• Supportive treatment
• Fluid restriction
• Daily blood count monitoring

Storage Conditions

• Store at 2-8°C

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