Criston 1 mg/vail (Injection)
1 mg vial: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Vincristine sulfate |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Acute leukemia
- Hodgkin's disease
- Non-Hodgkin's malignant lymphomas
- Rhabdomyosarcoma
- Neuroblastoma
- Wilms'tumor
Pharmacology
- Alkaloid obtained from the periwinkle plant
- White or slightly yellow, hygroscopic, amorphous or crystalline powder
- Freely soluble in water
- Slightly soluble in alcohol
- Triphasic serum decay pattern
- Liver as major excretory organ
- Binding in tissue
- Pharmacokinetic studies
- Salt of an alkaloid
- Major excretory organ in humans and animals
- Liver as excretory organ
Dosage & Administration
- Extreme care in calculating and administering the dose
- IV administration
- Fatal if given intrathecally
- Usual dose for adults: 1.4 mg/m2
- Usual dose for children: 1.5-2 mg/m2
- Initial dose for children weighing 10 kg or less: 0.05 mg/kg
- Combination use with L-asparaginase
- Solution injection into vein or tubing
- Further dilution with sodium chloride or dextrose injection
Interaction
- Increased incidence of bone-marrow depression with Allopurinol
- Additive neurotoxicity with asparaginase, isoniazid, and other drugs
- Increased myelosuppression with doxorubicin and prednisone
- Cellular uptake of methotrexate by malignant cells increasing
Contraindications
- Demyelinating form of Charcot-Marie-Tooth Syndrome
- Radiation therapy through ports including the liver
- Known hypersensitivity to vinca alkaloids or mannitol
Side Effects
- Reversible adverse reactions related to dosage
- Hair loss
- Neuromuscular adverse reactions
- Hypersensitivity reactions
- Autonomic toxicity
- Gastrointestinal effects
- Genitourinary hyperuricaemia
- Cardiovascular effects
- Neurologic effects
- Other effects
- Pregnancy Category D
Pregnancy & Lactation
- Pregnancy Category D
- No adequate and well-controlled studies in pregnant women
- Reported presence in human milk
- Not to be breastfed
Precautions & Warnings
- Extreme care in IV administration
- Needle position confirmation
- Leakage management
- Experienced physicians for cytotoxic chemotherapy
- Intramuscular, subcutaneous, or intrathecal administration avoidance
- Vesicant property and severe local reaction on extravasation
- Leucopenia risk considerations
- Acute shortness of breath and severe bronchospasm risk
- Storage in refrigerator at 2°C - 8°C
- Protection from light
- Keep out of reach of children
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Refrigerator storage at 2°C - 8°C
- Protection from freezing
- Protection from light