Avastin 100 mg/4 ml (IV Infusion)

100 mg vial: ৳ 23,511.64

Medicine Details

Category Details
Generic Bevacizumab
Company Roche bangladesh ltd
Also available as
Avastin 400 mg injection

Indications

  • Treatment of metastatic colorectal cancer with intravenous 5-fluorouracil-based chemotherapy
  • Treatment of metastatic colorectal cancer with fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy
  • First-line treatment of non-squamous non-small cell lung cancer with carboplatin and paclitaxel
  • Treatment of glioblastoma as a single agent for patients with progressive disease
  • Treatment of metastatic renal cell carcinoma with interferon alfa
  • Treatment of cervical cancer in combination with paclitaxel and cisplatin or paclitaxel and topotecan
  • Platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan
  • Platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment in combination with carboplatin and paclitaxel or carboplatin and gemcitabine

Pharmacology

  • Recombinant humanized monoclonal IgG1 antibody
  • Binds and inhibits biologic activity of vascular endothelial growth factor (VEGF)
  • Produced in a mammalian cell expression system
  • Clear to slightly opalescent, colorless to pale brown, sterile, pH 6.2 solution

Dosage

  • Recommended doses for different types of cancer
  • Different dosages for metastatic colorectal cancer, non-squamous non-small cell lung cancer, glioblastoma, metastatic renal cell carcinoma, cervical cancer, platinum-resistant and platinum-sensitive recurrent epithelial ovarian cancer

Administration

  • Infusion duration for first and subsequent infusions
  • Preparation for administration using aseptic technique
  • Dilution in 0.9% Sodium Chloride injection, USP

Interaction

  • Study demonstrating no significant effect on the pharmacokinetics of irinotecan
  • Administered as part of the FOLFIRI regimen

Contraindications

  • No contraindications listed in the manufacturer’s labeling

Side Effects

  • Most common adverse reactions

Pregnancy & Lactation

  • Potential for fetal harm based on animal studies
  • No data available regarding the presence in human milk
  • Recommendation against breastfeeding during treatment

Precautions & Warnings

  • Discontinuation in cases of perforation, fistula, arterial thromboembolic events, venous thromboembolic events, hypertension, posterior reversible encephalopathy syndrome, proteinuria, infusion reactions
  • Advising females of potential risk to fetus and need for effective contraception
  • Potential risk of ovarian failure
  • Geriatric use and pediatric use

Use in Special Populations

  • Safety, effectiveness and pharmacokinetic profile in pediatric patients not established
  • Cases of non-mandibular osteonecrosis observed in patients under 18 years
  • Insufficient information to determine the safety and efficacy in children with glioblastoma
  • Physeal dysplasia observed in juvenile cynomolgus monkeys

Overdose Effects

  • Effect of highest tested dose in humans
  • Associated adverse reactions

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Refrigeration at 2-8°C
  • Protect from light and freezing
  • Keep out of reach of children

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