Carboplatin Hexal 10 mg/ml (IV Infusion)
150 mg vial: ৳ 1,400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carboplatin |
| Company | Sandoz a novartis division |
Indications
- Initial treatment of advanced ovarian carcinoma of epithelial origin
- Palliative treatment of recurrent ovarian carcinoma
Pharmacology
- Alkylating agent
- Binds covalently to DNA
- Interferes with DNA structure and function
Dosage & Administration
- Intravenous administration
- Recommended dosage of 400 mg/m2
- Dosage adjustment for patients with risk factors
- Determination of hematologic nadir for dosage adjustment
- Procedures for proper handling and disposal of anti-cancer drugs
Interaction
- Not to be mixed with other drugs
- Potentiation of renal effects of neurotoxic compounds
Contraindications
- Severe renal impairment
- Severe myelosuppression
- History of severe allergic reactions to Carboplatin
- Patients with bleeding tumors
Side Effects
- Bone marrow suppression
- Thrombocytopenia
- Neutropenia
- Leucopenia
- Anaemia
- Nephrotoxicity
- Gastrointestinal toxicity
- Allergic reactions
- Hepatic Toxicity
- Neurotoxicity
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in human milk
Precautions & Warnings
- Supervision of qualified physician
- Monitoring of peripheral blood counts
- Neurologic evaluations
- Discontinuation in case of abnormal depression of bone marrow or renal/hepatic function
- Careful planning for combination therapy with myelosuppressive compounds
- Supportive transfusional therapy for myelosuppression
- Nausea and vomiting management
- Avoidance of combination with nephrotoxic compounds
- Management of allergic reactions
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store below 25°C
- Do not refrigerate
- Keep out of reach of children