Carboplat 10 mg/ml (IV Infusion)
150 mg vial: ৳ 1,400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carboplatin |
| Company | Beacon pharmaceuticals plc |
Indications
- Initial treatment of advanced ovarian carcinoma
- Palliative treatment of recurrent ovarian carcinoma
- Combination with other chemotherapeutic agents
Pharmacology
- Alkylating agent
- Covalently binds to DNA
- Modifies cell cycle
- Interferes with DNA structure and function
Dosage & Administration
- Intravenous route only
- Recommended dosage for previously untreated adult patients
- Dosage adjustment for patients with risk factors
- Determination of hematologic nadir for dosage adjustment
Interaction
- Should not be mixed with other drugs
- Potentiate renal effects of neurotoxic compounds
Contraindications
- Severe renal impairment
- Severe myelosuppression
- History of severe allergic reactions to Carboplatin
- Bleeding tumors
Side Effects
- Haematologic toxicity
- Nephrotoxicity
- Gastrointestinal toxicity
- Allergic reactions
- Hepatic Toxicity
- Neurotoxicity
Pregnancy & Lactation
- Pregnancy Category D
- No adequate and well-controlled studies in pregnant women
- Excretion in human milk
Precautions & Warnings
- Administration under supervision of qualified physician
- Management of therapy and complications
- Close monitoring of peripheral blood counts and renal and hepatic function tests
- Discontinue drug if abnormal depression of the bone marrow or abnormal renal or hepatic function is seen
- Careful planning of combination therapy
- Supportive transfusional therapy
- Monitoring of renal function impairment
- Management of allergic reactions
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store below 25°C in a dry place
- Do not Refrigerate
- Keep out of reach of children