Cisplatin Hexal 1 mg/ml (IV Infusion)
10 mg vial: ৳ 419.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cisplatin |
| Company | Sandoz a novartis division |
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Small Cell Lung Carcinoma
Pharmacology
- Platinum Compound
- Interstrand Cross Links
- Inhibition of DNA Synthesis
- Inhibition of Protein and RNA Synthesis
- Non Phase-Specific in Cell Cycle
Dosage & Administration
- Administration by Slow Intravenous Infusion
- Avoid Rapid Intravenous Injection
- Avoid Aluminum Contamination
- Different Doses for Different Tumor Types
Interaction
- Additive Toxicity with Antineoplastic Drugs
- Nephrotoxic Drugs Interaction
- Ototoxic Drugs Interaction
- Alteration in Renal Elimination of Other Drugs
- Interaction with Anticonvulsant Agents
- Interaction with Antigout Agents
Contraindications
- Pre-existing Renal Impairment
- Hypersensitivity to Cisplatin or Platinum Compounds
- Myelosuppressed Patients
- Patients with Hearing Impairment
Side Effects
- Severe Nausea and Vomiting
- Electrolyte Disturbances
- Hypomagnesemia
- Hypocalcemia
- Hypokalemia
- Renal Tubular Dysfunction
Pregnancy & Lactation
- Pregnancy Category D
- No Well-Controlled Studies in Pregnant Women
- Presence in Human Milk
Precautions & Warnings
- Cumulative Nephrotoxicity
- Evaluation of Renal Function and Serum Electrolytes
- Pre-treatment Intravenous Hydration
- Monitoring of Bone Marrow Function
- Monitoring of Hearing Function
- Neurologic Examination
- Management of Nausea and Vomiting
- Carcinogenicity Risk
- Dental Precautions
Overdose Effects
- Kidney Failure
- Liver Failure
- Deafness
- Ocular Toxicity
- Myelosuppression
- Neuritis
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store at 25°C
- Do Not Refrigerate
- Protect from Light
- Keep Out of Reach of Children