Platosin 1 mg/ml (IV Infusion)

10 mg vial: ৳ 1,687.00

Medicine Details

Category Details
Generic Cisplatin
Company Pharmachemie bv

Indications

  • Metastatic Testicular Tumors
  • Metastatic Ovarian Tumors
  • Advanced Bladder Cancer
  • Small Cell Lung Carcinoma

Pharmacology

Cisplatin is a platinum compound that produces intra- and interstrand cross links, modifies DNA structure, inhibits DNA synthesis, and inhibits protein and RNA synthesis.

Dosage & Administration

  • Metastatic Testicular Tumors: 20 mg/m2 IV daily for 5 days per cycle
  • Metastatic Ovarian Tumors: 75 to 100 mg/m2 IV per cycle once every 4 weeks
  • Advanced Bladder Cancer: 50 to 70 mg/m2 IV per cycle once every 3 to 4 weeks
  • Non Small Cell Lung Carcinoma: 75 mg/m2 IV every three weeks

Interactions

  • Additive toxicity with antineoplastic drugs
  • Nephrotoxicity potentiation with aminoglycoside antibiotics
  • Potential ototoxicity with aminoglycoside antibiotics or loop diuretics
  • Alteration of renal elimination of bleomycin and methotrexate
  • Potential decreased serum concentrations of phenytoin
  • Elevated concentration of blood uric acid when concurrently receiving antigout agents

Contraindications

  • Pre-existing renal impairment
  • History of hypersensitivity to Cisplatin or Platinum containing compounds
  • Myelosuppressed patients
  • Patients with hearing impairment

Side Effects

  • Severe nausea and vomiting
  • Electrolyte disturbances (hypomagnesemia, hypocalcemia, hypokalemia)
  • Renal tubular dysfunction

Pregnancy & Lactation

Pregnancy Category D, Cisplatin found in human milk

Precautions & Warnings

  • Renal function: Produces cumulative nephrotoxicity, requires evaluation of renal function and serum electrolyte, maintenance of urine output, and special care for Platosin-treated patients
  • Bone marrow function: Requires monitoring of peripheral blood counts and precautions for severe thrombocytopenia and leukopenia
  • Hearing function: May produce cumulative ototoxicity, requires audiometry prior to therapy and repeated audiograms
  • CNS functions: Induces neurotoxicity, necessitates neurologic examination and observation for anaphylactoid reactions
  • Nausea and Vomiting: Marked nausea and vomiting may occur
  • Carcinogenicity: Potential for secondary malignancies
  • Dental: Increased incidence of microbial infection and delayed healing

Overdose Effects

May result in kidney failure, liver failure, deafness, ocular toxicity, myelosuppression, intractable nausea and vomiting, and death

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Store the vial in original carton at 25°C, protect from light, and keep out of the reach of children

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