Platinex 1 mg/ml (IV Infusion)
10 mg vial: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cisplatin |
| Company | Beacon pharmaceuticals plc |
Title
- Platinex
Categories
- Antineoplastic Agent
- Chemotherapy
- Cytotoxic Chemotherapy
Description
- Cisplatin injection for the treatment of metastatic testicular tumors, metastatic ovarian tumors, advanced bladder cancer, and small cell lung carcinoma.
Dosage Administration
- Administered by slow intravenous infusion
- Dosage varies based on the type of tumor being treated
Pharmacology
- Platinum compound
- Forms intra-and interstrand cross links
- Modifies DNA structure
- Inhibits DNA synthesis
- Inhibits protein and RNA synthesis
- Not phase-specific in the cell cycle
Indications
- Metastatic testicular tumors
- Metastatic ovarian tumors
- Advanced bladder cancer
- Small cell lung carcinoma
Interaction
- Additive toxicity with antineoplastic drugs
- Nephrotoxic drug interactions
- Ototoxic drug interactions
- Renally excreted drug interactions
- Anticonvulsant agent interactions
- Antigout agent interactions
Contraindications
- Pre-existing renal impairment
- Hypersensitivity to Cisplatin or Platinum containing compounds
- Myelosuppresed patients
- Patients with hearing impairment
Side Effects
- Severe nausea and vomiting
- Electrolyte disturbances
- Renal tubular dysfunction
- Hypomagnesemia
- Hypocalcemia
- Hypokalemia
Pregnancy Lactation
- Pregnancy Category D
- Excretion in human milk
Precautions Warnings
- Cumulative nephrotoxicity
- Renal function evaluation
- Peripheral blood count monitoring
- Hearing function evaluation
- Neurologic examination
- Nausea and vomiting management
- Risk of secondary malignancies
- Dental precautions
Overdose Effects
- Kidney failure
- Liver failure
- Deafness
- Ocular toxicity
- Myelosuppression
- Intractable nausea and vomiting
- Neuritis
- Death
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store in original carton at 25°C
- Do not refrigerate
- Protect from light
- Keep out of the reach of children