Platinex 1 mg/ml (IV Infusion)

10 mg vial: ৳ 250.00

Medicine Details

Category	Details
Generic	Cisplatin
Company	Beacon pharmaceuticals plc

Title

Platinex

Categories

Antineoplastic Agent
Chemotherapy
Cytotoxic Chemotherapy

Description

Cisplatin injection for the treatment of metastatic testicular tumors, metastatic ovarian tumors, advanced bladder cancer, and small cell lung carcinoma.

Dosage Administration

Administered by slow intravenous infusion
Dosage varies based on the type of tumor being treated

Pharmacology

Platinum compound
Forms intra-and interstrand cross links
Modifies DNA structure
Inhibits DNA synthesis
Inhibits protein and RNA synthesis
Not phase-specific in the cell cycle

Indications

Metastatic testicular tumors
Metastatic ovarian tumors
Advanced bladder cancer
Small cell lung carcinoma

Interaction

Additive toxicity with antineoplastic drugs
Nephrotoxic drug interactions
Ototoxic drug interactions
Renally excreted drug interactions
Anticonvulsant agent interactions
Antigout agent interactions

Contraindications

Pre-existing renal impairment
Hypersensitivity to Cisplatin or Platinum containing compounds
Myelosuppresed patients
Patients with hearing impairment

Side Effects

Severe nausea and vomiting
Electrolyte disturbances
Renal tubular dysfunction
Hypomagnesemia
Hypocalcemia
Hypokalemia

Pregnancy Lactation

Pregnancy Category D
Excretion in human milk

Precautions Warnings

Cumulative nephrotoxicity
Renal function evaluation
Peripheral blood count monitoring
Hearing function evaluation
Neurologic examination
Nausea and vomiting management
Risk of secondary malignancies
Dental precautions

Overdose Effects

Kidney failure
Liver failure
Deafness
Ocular toxicity
Myelosuppression
Intractable nausea and vomiting
Neuritis
Death

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Store in original carton at 25°C
Do not refrigerate
Protect from light
Keep out of the reach of children

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