Taxotere 20 mg/vial (IV Infusion)

20 mg vial: ৳ 9,180.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Synovia pharma plc
Also available as
Taxotere 80 mg injection

Title

  • Taxotere

Categories

  • Antineoplastic Agent
  • Chemotherapy
  • Cytotoxic Chemotherapy
  • Cancer Medication

Description

  • Taxotere is a microtubule inhibitor indicated for various types of cancer including Breast Cancer (BC), Non-small Cell Lung Cancer (NSCLC), Castration-Resistant Prostate Cancer (CRPC), Gastric Adenocarcinoma (GC), and Squamous Cell Carcinoma of the Head and Neck (SCCHN). It acts by disrupting the microtubular network in cells that is essential for vital mitotic and interphase cellular functions.

Dosage and administration

  • Administered intravenously over 1 hr every 3 weeks
  • Dosage varies based on the type of cancer being treated

Pharmacology

  • Acts by disrupting the microtubular network in cells
  • Promotes the assembly of tubulin into stable microtubules while inhibiting their disassembly
  • Binds to free tubulin, decreasing the critical intracellular concentration of tubulin

Interaction

  • Taxotere is a CYP3A4 substrate
  • Metabolism may be modified by concomitant administration of other compounds

Contraindications

  • Contraindicated in patients with neutrophil counts of <1500 cells/mm3
  • Contraindicated in patients with a history of severe hypersensitivity reactions to docetaxel or to other drugs formulated with polysorbate 80

Side effects

  • Common adverse reactions include infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, and more

Pregnancy and lactation

  • Can cause fetal harm when administered to a pregnant woman
  • No information regarding presence in human milk or effects on breastfed child

Precautions and warnings

  • Should be administered under the supervision of a physician experienced in the use of antineoplastic agents
  • Higher risk of severe adverse reactions in patients with hepatic impairment

Overdose effects

  • No known antidote for docetaxel overdose
  • Expected complications include bone marrow suppression, peripheral neurotoxicity, and mucositis

Storage conditions

  • Store between 2°C and 25°C and protected from light

Therapeutic class

  • Cytotoxic Chemotherapy

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