Docexan 20 mg/vial (IV Infusion)

Title

• Docexan

Categories

• Antineoplastic Agent
• Cytotoxic Chemotherapy

Indications

• Breast Cancer (BC)
• Non-small Cell Lung Cancer (NSCLC)
• Castration-Resistant Prostate Cancer (CRPC)
• Gastric Adenocarcinoma (GC)
• Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Pharmacology

• Disrupts microtubular network in cells
• Promotes the assembly of tubulin into stable microtubules
• Inhibits disassembly of microtubules
• Binds to free tubulin
• Decreases critical intracellular concentration of tubulin

Dosage & Administration

• Administered intravenously (IV) over 1 hr every 3 weeks
• Dosage ranges for different cancer types
• Facility equipped to manage complications needed for administration
• Use of PVC equipment not recommended
• Premedication with oral corticosteroids required
• Dose adjustment as needed

Interaction

• CYP3A4 substrate
• Metabolism may be modified by concomitant administration of certain compounds

Contraindications

• Patients with neutrophil counts of <1500 cells/mm3
• History of severe hypersensitivity reactions to docetaxel
• History of severe hypersensitivity reactions to drugs formulated with polysorbate 80

Side Effects

• Common adverse reactions across all indications
• Incidence varies depending on the indication
• Descriptions of various adverse reactions

Pregnancy & Lactation

• Potential fetal harm during pregnancy
• No information regarding presence in human milk or effects on the breastfed child
• No animal lactation studies conducted

Precautions & Warnings

• Administered under supervision of experienced physician
• Higher risk for severe adverse reactions in patients with hepatic impairment
• Not recommended for patients with neutrophil counts below 1,500 cells/mm3
• Reports of fatal cases of enterocolitis and severe hypersensitivity reactions

Overdose Effects

• No known antidote for overdose
• Expected complications of overdose
• Recommended therapeutic measures for overdose

Therapeutic Class

• Cytotoxic Chemotherapy

Storage Conditions

• Store between 2°C and 25°C
• Protected from light
• Freezing does not adversely affect the product

Related Brands

• Taxotere 20 mg/vial (IV Infusion) - synovia-pharma-plc
• Docetax 20 mg/vial (IV Infusion) - techno-drugs-ltd