Apuldon 5 mg/ml (Pediatric Drops)
15 ml drop: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Aristopharma ltd |
| Also available as |
Title
Apuldon 5 mg/ml Pediatric Drop
Categories
- Medicine
- Pharmaceuticals
- Healthcare
Description
A dopamine antagonist medication used to treat symptoms such as dyspeptic symptom complex, acute nausea and vomiting, and Parkinson's disease. It also aids in speeding barium transit in follow-through radiological studies.
Form
Oral suspension
Dosage
- 10-20 mg for adults every 6-8 hours daily
- 2-4 ml/10 kg body weight for children every 6-8 hours daily
Administration
- Should be taken 15-30 minutes before meals
- Maximum daily dose for adults is 80 mg
- Suppositories for rectal administration
Pharmacology
Blocks dopamine receptors in the Chemoreceptor Trigger Zone and stomach, enhances gastrointestinal motility, gastric emptying, and esophageal peristalsis, and regulates pyloric contraction.
Interaction
- Antagonized by anticholinergic drugs
- Lowered oral bioavailability with antacids and antisecretory drugs
- Inhibited by CYP3A4 inhibitors
Contraindications
- Hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage, obstruction, or perforation
- Prolactin-releasing pituitary tumor
SideEffects
- Transient intestinal cramps
- Extrapyramidal phenomena (rare)
- Hyperprolactinaemia
- Allergic reactions (rare)
PregnancyAndLactation
- Only justified use in first trimester of pregnancy
- Excreted in breast milk
- Not recommended for breastfeeding unless benefits outweigh risks
PrecautionsAndWarnings
- Caution in children due to risk of extrapyramidal reactions
- Caution in hepatic impairment
SpecialPopulations
- Caution in infants due to immature blood-brain barrier
- Caution in hepatic and severe renal impairment
OverdoseEffects
- Drowsiness, disorientation, extrapyramidal reactions
- Activated charcoal may be administered
- Anticholinergic drugs may help control extrapyramidal reactions
TherapeuticClass
Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
StorageConditions
Store below 30°C, Protected from light & moisture, Keep out of children's reach
ChemicalStructure
- MolecularFormula: C22H24ClN5O2
- ChemicalStructureImage: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg
CommonQuestions
- Uses: Treats nausea and vomiting
- QuickTips:
- Helps relieve nausea, vomiting, and indigestion
- May cause dizziness and sleepiness
- Avoid alcohol consumption
- Dry mouth may occur as a side effect
- Inform your doctor of any adverse symptoms