Erlonix 150 mg (Tablet)
Unit Price: ৳ 750.00 (5 x 6: ৳ 22,500.00)
Strip Price: ৳ 4,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Erlotinib |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- First-line treatment of patients with metastatic Non-Small Cell Lung cancer (NSCLC)
- Maintenance treatment of patients with locally advanced or metastatic NSCLC
- Treatment of locally advanced or metastatic NSCLC after failure of at least one prior chemotherapy regimen
- First-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer
Description
- Chemical name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)4-quinazolinamine
- Inhibits the kinase activity of EGFR
- Reversibly inhibits autophosphorylation of tyrosine residues associated with the receptor
Dosage & Administration
- Recommended daily dose for NSCLC: 150 mg on an empty stomach
- Recommended daily dose for pancreatic cancer: 100 mg in combination with gemcitabine on an empty stomach
- Reduced dosage for severe reactions with CYP3A4 inhibitors
- Increased dosage for concomitant use with CYP3A4 inducers
Interaction
- Interacts with coumarin-derived anticoagulants
- Metabolized predominantly by CYP3A4
- Co-treatment with ketoconazole increases Erlonix AUC by 67%
Side Effects
- Common adverse reactions: rash, diarrhea, anorexia, fatigue, dyspnea, cough, nausea, vomiting
- Serious adverse reactions may include interstitial lung disease, renal failure, hepatotoxicity, gastrointestinal perforation
Pregnancy & Lactation
- Pregnancy category D
- Can cause fetal harm
- Not known whether present in human milk
Precautions & Warnings
- Occurrence of Interstitial Lung Disease (ILD) in 1.1% of patients
- Monitor renal function and electrolytes
- Monitor periodic liver testing for hepatotoxicity
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- No overall differences in safety or efficacy observed between subjects 65 years and older and those younger than 65
Overdose Effects
- Tolerated single oral doses up to 1,000 mg in healthy subjects
- Weekly doses up to 1,600 mg in cancer patients have been tolerated
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store at a temperature not exceeding 30°C
- Protect from light and moisture