Tasigna 200 mg (Capsule)

Unit Price: ৳ 3,040.00 (2 x 14: ৳ 85,120.00)
Strip Price: ৳ 42,560.00

Medicine Details

Category Details
Generic Nilotinib
Company Novartis bangladesh ltd

Indications

  • Treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase
  • Treatment of chronic phase (CP) and accelerated phase (AP) Ph+ CML in adult patients resistant to or intolerant to prior therapy

Pharmacology

  • Inhibits the tyrosine kinase activity of the BCR-ABL protein
  • Fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib
  • Inhibits TEL-platelet-derived growth factor receptor-beta (TEL-PDGFRbeta)
  • Inhibits c-Kit receptor kinase

Dosage & Administration

  • Recommended Dose: Newly diagnosed Ph+ CML-CP: 300 mg orally twice daily
  • Resistant or intolerant Ph+ CML-CP and CML-AP: 400 mg orally twice daily
  • Administer Nilotinib approximately 12 hours apart and must not take with food

Interaction

  • Drugs that inhibit gastric acid secretion may reduce solubility and bioavailability of Tasigna

Contraindications

  • Hypokalaemia
  • Hypomagnesaemia
  • Long QT syndrome
  • Concomitant use with potent CYP3A4 inhibitors or antiarrhythmics and other QT prolonging drugs
  • Concomitant use with potent CYP3A4 inducers

Side Effects

  • Rash
  • Pruritus
  • Hepatotoxicity
  • Headache
  • Fatigue
  • GI disturbances (nausea, constipation, diarrhoea)
  • Alopecia
  • Muscle spasms
  • Arthralgia
  • Myalgia
  • Pain (e.g. musculoskeletal or chest pain)
  • Oedema
  • Insomnia
  • Dizziness
  • Thrombotic disorders or haemorrhage

Pregnancy & Lactation

  • Pregnancy Category D
  • Positive evidence of human foetal risk
  • Sexually active female patients should use effective contraception

Precautions & Warnings

  • History of pancreatitis
  • Hepatic impairment
  • Maintain adequate hydration and correct electrolyte imbalances prior to therapy

Overdose Effects

  • Neutropenia
  • Vomiting
  • Drowsiness

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store in a cool and dry place, away from light
  • Keep out of the reach of children

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