Atidon 10 mg (Tablet)
Unit Price: ৳ 2.00 (50's pack: ৳ 100.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Asiatic laboratories ltd |
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Chemoreceptor Trigger Zone (CTZ) blocker
- Gastroprokinetic action
- Influence on gastrointestinal motility
- Weak penetration across blood-brain barrier
- Restores normal motility and tone of the upper gastrointestinal tract
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Lowers esophageal sphincter pressure
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Usual recommended oral dose for adults and children
- Different dosages for dyspeptic symptom and acute/sub-acute conditions
- Rectal administration for adults and children
- Maximum daily dose for adult and pediatric use
Interaction
- Concomitant administration of anticholinergic drugs
- Antacids and antisecretory drugs interactions
- Main metabolic pathway through CYP3A4
- In vitro data suggesting enzyme inhibition
- Examples of CYP3A4 inhibitors
- Interaction with neuroleptics and dopaminergic agonists
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal stimulation risks
- Prolactin releasing pituitary tumor
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Possible allergic reactions like rash and urticaria
Pregnancy & Lactation
- Use in first trimester if justified by therapeutic benefit
- No evidence of increase in risk of malformations in humans
- Excretion in breast milk
- Not recommended for nursing mothers
Precautions & Warnings
- Absolute caution in the case of children
- Increased risk of extra-pyramidal reactions in young children
- High metabolism in liver
- Caution in patients with hepatic impairment
Use in Special Populations
- Use in infants with caution and close medical supervision
- Caution in liver disorders
- Caution in kidney disorders
- Review of patients on prolonged therapy
Overdose Effects
- Symptoms of overdosage
- Recommendations for management
- Use of anticholinergic, antiparkinson drugs
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular formula
- Chemical structure image link
Common Questions about Atidon 10 mg Tablet
- Medical uses
- Quick tips for usage
- Advice on alcohol consumption
- Guidance on side effects
- Duration of usage