Paclitaxel Sandoz 6 mg/ml (IV Infusion)
30 mg vial: ৳ 4,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paclitaxel |
| Company | Sandoz a novartis division |
Indications
- First-line therapy for advanced carcinoma of the ovary
- Treatment of node-positive breast cancer
- Treatment of metastatic breast cancer
- Treatment of non-small cell lung cancer
- Treatment of Kaposi's Sarcoma
- Treatment of Gastric Carcinoma
Pharmacology
Promotes assembly of microtubules, stabilizes microtubules, inhibits dynamic reorganization of the microtubule network, induces abnormal arrays of microtubules
Dosage & Administration
- First-line treatment of ovarian cancer
- Second-line treatment of ovarian cancer
- Adjuvant chemotherapy in breast carcinoma
- First-line chemotherapy of breast carcinoma
- Second-line chemotherapy of breast carcinoma
- Advanced non-small-cell lung cancer treatment
- Treatment of AIDS-related KS
- Dose adjustment
Interaction
- Cisplatin interaction
- Doxorubicin interaction
- Metabolism of active substances in the liver
Contraindications
- Severe hypersensitivity reactions to paclitaxel
- Contraindicated during lactation
- Baseline neutrophils & platelets count
Side Effects
- Low blood counts
- Hair loss
- Arthralgias and myalgias
- Peripheral neuropathy
- Nausea and vomiting
- Diarrhea
- Hypersensitivity reaction
- Fever
- Swelling of the feet or ankles
- Liver problems
- Low blood pressure
- Darkening of the skin
Pregnancy & Lactation
Category D for pregnancy, contraindicated during lactation
Precautions & Warnings
- Administered under the supervision of a physician experienced in cancer chemotherapeutic agents
- Possibility of extravasation
- Hypersensitivity reactions monitoring
- Bone marrow suppression
- Cardiac conduction abnormalities
Use in Special Populations
- Severe neutropenia dosage adjustment
- Use in hepatic impairment
- Pediatric use
Overdose Effects
No known antidote, closely monitored for primary toxicities
Reconstitution
Dilution prior to infusion, stability of solutions, visual inspection required
Storage Conditions
Store below 30°C, protect from light, use only freshly prepared solution