Xelpac 6 mg/ml (IV Infusion)
30 mg vial: ৳ 1,700.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paclitaxel |
| Company | Beacon pharmaceuticals plc |
Indications
- First line therapy for advanced ovarian carcinoma
- Adjuvant treatment of node-positive breast cancer
- Treatment of breast cancer following failure of combination chemotherapy
- Treatment of advanced or metastatic breast cancer
- First line treatment of non-small cell lung carcinoma
- Second line treatment of AIDS related Kaposi's Sarcoma
- Treatment of Gastric Carcinoma
Pharmacology
- Promotes assembly of microtubules
- Stabilizes microtubules
- Inhibits normal dynamic reorganization of microtubule network
- Induces abnormal arrays of microtubules
Dosage & Administration
- Administered in combination with cisplatin
- Different dosages based on treatment line
- Different dosages for different types of cancer
- Requires premedication to prevent hypersensitivity reactions
Interaction
- No affected clearance by cimetidine premedication
- Interaction with cisplatin leading to myelosuppression
- Interaction with doxorubicin affecting elimination
- Metabolism catalyzed by specific cytochrome P450 isoenzymes
Contraindications
- Severe hypersensitivity reactions
- Baseline neutrophil and platelet counts
- Contraindicated during lactation
- Severe hepatic impairment
Side Effects
- Low blood counts
- Hair loss
- Nausea and vomiting
- Peripheral neuropathy
- Hypersensitivity reactions
- Edema
- Liver problems
Pregnancy & Lactation
- Pregnancy Category D
- May cause fetal harm
- Contraindicated during lactation
Precautions & Warnings
- Administered under supervision of experienced physician
- Significant hypersensitivity reactions possible
- Bone marrow suppression
- Cardiac conduction abnormalities reported
Use in Special Populations
- Dose reduction for specific conditions
- Hepatic impairment considerations
- Not recommended for pediatric use
Overdose Effects
- No known antidote
- Toxicities include bone marrow suppression and neurotoxicity
- Monitor closely
Reconstitution
- Must be diluted before infusion
- Dilution in specific types of solutions
- Physically and chemically stable for up to 27 hours
Storage Conditions
- Store below 30°C
- Protect from light
- Use only freshly prepared solution