Certican 0.50 mg (Tablet)

Unit Price: ৳ 250.00 (6 x 10: ৳ 15,000.00)

Strip Price: ৳ 2,500.00

Medicine Details

Category	Details
Generic	Everolimus
Company	Novartis bangladesh ltd
Also available as	Certican 025 mg tablet Certican 075 mg tablet Afinitor 10 mg tablet Afinitor 5 mg tablet

Indications

Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer
Advanced Neuroendocrine Tumors
Advanced Renal Cell Carcinoma
Renal Angiomyolipoma With Tuberous Sclerosis Complex
Subependymal Giant Cell Astrocytoma

Pharmacology

Proliferation signal inhibitor
Immunosuppressive effect
Cell cycle arrest
FKBP-12 complex formation
Cell metabolism regulation

Dosage & Administration

Initial dosage for kidney & heart transplant
Initial dosage for hepatic transplant
Recommended dosage for breast cancer, NET, RCC, and Renal Angiomyolipoma
Administration instructions

Interaction

CYP3A4 inhibitors/inducers
CYP2D6 substrates with narrow therapeutic index
PgP inhibitors
Rifampicin
ACE inhibitors
Grapefruit juice
Live vaccines

Contraindications

Hypersensitivity to active substance or other rapamycin derivatives
Anaphylaxis
Respiratory symptoms
Angioedema

Side Effects

Stomatitis
Constipation
Infections
Asthenia
Fatigue
Cough
Rash
Anemia
Nausea
Anorexia
Edema
Dyspnea
Pyrexia
Vomiting
Headache
Epistaxis
Decreased lymphocytes
Increased glucose
Pneumonitis
Pruritus
Dry skin
Decreased Hgb
Menstrual irregularities
Dysgeusia
Hypertension
Hemorrhage
Tachycardia
CHF

Pregnancy & Lactation

Pregnancy Category D
Risk of human fetal effects
Lactation precautions

Precautions & Warnings

Increased risk with ACE inhibitor therapy
Interstitial lung disease/pneumonitis monitoring
Immunosuppressive effects
Infection risk monitoring
Mouth ulcers and stomatitis management
Wound healing delay
Renal failure cases
Angioedema and fluid accumulation
Hematologic and metabolic parameter monitoring
Impaired male fertility
Avoidance of live vaccines during treatment
Fetal harm potential

Therapeutic Class

Immunosuppressant

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