Certican 0.75 mg (Tablet)
Unit Price: ৳ 375.00 (6 x 10: ৳ 22,500.00)
Strip Price: ৳ 3,750.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Everolimus |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer
- Advanced Neuroendocrine Tumors
- Advanced Renal Cell Carcinoma
- Renal Angiomyolipoma With Tuberous Sclerosis Complex
- Subependymal Giant Cell Astrocytoma
- Organ rejection prophylaxis in renal or cardiac transplant
- Organ rejection prophylaxis in hepatic transplant
Pharmacology
- Proliferation signal inhibitor
- Immunosuppressive effect
- Inhibition of T cell proliferation
- Inhibition of cell cycle at G1 stage
- Complex formation with cytoplasmic protein FKBP-12
- Inhibition of p70 S6 kinase phosphorylation
- Interference with FRAP function
Dosage & Administration
- Initial dosage after transplantation
- Dose for different types of transplants
- Recommended daily dose for specific indications
- Administration with or without food
- Swallowing whole with water
- Duration of treatment
Interaction
- CYP3A4 inhibitors and/or inducers
- CYP2D6 substrates with narrow therapeutic index
- PgP inhibitors
- Rifampicin
- ACE inhibitors
- Grapefruit juice
- Live vaccines
Contraindications
- Hypersensitivity reactions
- Manifestation of hypersensitivity symptoms
- Anaphylaxis
- Dyspnea
- Flushing
- Chest pain
- Angioedema
Side Effects
- Stomatitis
- Constipation
- Infections
- Asthenia
- Fatigue
- Cough
- Diarrhea
- Rash
- Anemia
- Nausea
- Anorexia
- Edema
- Peripheral edema
- Dyspnea
- Pyrexia
- Vomiting
- Headache
- Epistaxis
- Decreased lymphocytes
- Increased glucose
- Pneumonitis
- Pruritus
- Dry skin
- Decreased Hgb
- Menstrual irregularities
- Dysgeusia
- Hypertension
- Hemorrhage
- Tachycardia
- CHF
Pregnancy & Lactation
- Pregnancy Category D
- Positive evidence of human fetal risk
- Distribution into breast milk unknown
- Not recommended during lactation
Precautions & Warnings
- Increased risk for angioedema with ACE inhibitor therapy
- Interstitial lung disease/noninfectious pneumonitis
- Symptom and radiological monitoring
- Immunosuppressive effects on infection risk
- Severe or fatal infections
- Pneumocystis jiroveci pneumonia
- Mouth ulcers, stomatitis, and oral mucositis management
- Delay in wound healing
- Renal failure cases
- Angioedema and fluid accumulation
- Hematologic and renal parameter monitoring
- Impairment of male fertility
- Avoidance of live vaccines
- Fetal harm risk
- Highly effective contraception advice for female patients
Therapeutic Class
- Immunosuppressant