Avomit 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Chemist laboratories ltd |
| Also available as |
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Epigastric sense of fullness
- Abdominal distension
- Upper abdominal pain
- Eructation
- Flatulence
- Early satiety
- Nausea
- Vomiting
- Heartburn
- Non-ulcer dyspepsia
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Chemoreceptor Trigger Zone (CTZ) blocking
- Stomach dopamine receptor blocking
- Gastroprokinetic action
- Gastrointestinal motility regulation
- Weak blood-brain barrier penetration
- Restores normal motility
- Enhances gastric emptying
- Increases peristalsis
- Regulates pylorus contraction
Dosage & Administration
- Oral administration
- Pre-meal intake
- Adult dose: 10-20 mg
- Children dose: 2-4 ml/10kg body weight
- Acute nausea dose: 20 mg
- Rectal administration
- Adult rectal dose: 30-60 mg
- Children rectal dose: up to 30 mg
- Maximum daily dose: 80 mg
- Dosage frequency every 6-8 hours
Interaction
- Anticholinergic drugs interaction
- Antacid interaction
- CYP3A4 metabolic pathway
- Inhibition of enzyme
- CYP3A4 inhibitors
- Neuroleptics interaction
- Dopaminergic agonists interaction
Contraindications
- Hypersensitivity
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Prolactin releasing pituitary tumor
Side Effects
- Intestinal cramps
- Extrapyramidal phenomena
- Increase in plasma prolactin level
- Neurological side effects
- Galactorrhea
- Gynecomastia
- Allergic reactions
- Rash
- Urticaria
Pregnancy & Lactation
- Teratogenic effects
- First trimester use
- Excretion in breast milk
- Breastfeeding caution
- Plasma concentrations
Precautions & Warnings
- Caution in children
- Extra-pyramidal reactions risk
- Liver metabolism caution
- Hepatic impairment caution
Use in Special Populations
- Infant caution
- Blood-brain barrier penetration
- Liver disorders caution
- Kidney disorders caution
- Renal insufficiency
- Impaired kidney function
- Review in prolonged therapy
Overdose Effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Activated charcoal administration
- Close observation
- Anticholinergic drugs aid
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light
- Protected from moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image
Common Questions about Avomit 5 mg/5 ml Suspension
- Usage information
- Quick tips for usage
- Cautionary advice
- Avoidance guidelines