Crilomus 0.5 mg (Capsule)
Unit Price: ৳ 28.00 (5 x 10: ৳ 1,400.00)
Strip Price: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tacrolimus monohydrate oral |
| Company | Sandoz a novartis division |
| Also available as |
Indications
- Prophylaxis of organ rejection
- Adult and pediatric patients
- Allogeneic liver transplants
- Allogeneic kidney transplants
- Allogeneic heart transplants
- Allogeneic lung transplants
- Combination with other immunosuppressants
Pharmacology
- Binds to FKBP-12
- Inhibits phosphatase activity of calcineurin
- Inhibits dephosphorylation and translocation of various factors
- Inhibits expression and production of several cytokines
- Inhibits IL-2 receptor expression
- Induces apoptosis
- Produces transforming growth factor beta
Dosage & Administration
- Recommended oral starting doses
- Delayed administration for kidney transplant patients
- Initial oral dosage in adults and children
- Whole blood trough concentration range
- Dose adjustment for cystic fibrosis patients
Interaction
- Mycophenolic Acid Products
- Nelfinavir and Grapefruit Juice
- CYP3A Inhibitors
- CYP3A4 Inducers
- Cannabidiol co-administration
Contraindications
- Hypersensitivity to tacrolimus
- Hypersensitivity to HCO-60
Side Effects
- Abnormal renal function
- Hypertension
- Diabetes mellitus
- Fever
- CMV infection
- Tremor
- Hyperglycemia
- Leukopenia
- Infection
- Anemia
- Bronchitis
- Pericardial effusion
- Urinary tract infection
- Constipation
- Diarrhea
- Headache
- Abdominal pain
- Insomnia
- Paresthesia
- Peripheral edema
- Nausea
- Hyperkalemia
- Hypomagnesemia
- Hyperlipemia
Pregnancy & Lactation
- Potential fetal harm
Precautions & Warnings
- Not Interchangeable with Extended-Release Products
- New Onset Diabetes After Transplant
- Nephrotoxicity
- Neurotoxicity
- Hyperkalemia
- Hypertension
- Anaphylactic Reactions
- Not recommended for use with sirolimus
- Myocardial Hypertrophy
- Immunizations
- Pure Red Cell Aplasia
- Thrombotic Microangiopathy
- Thrombocytopenic Purpura
Overdose Effects
- Acute overdosages
- Adverse reactions
- General supportive measures
- Specific symptom treatment
Therapeutic Class
- Drugs affecting the immune response
Storage Conditions
- Store below 30°C
- Dry place
- Away from light and moisture
- Keep out of the reach of children