Crilomus 1 mg (Capsule)
Unit Price: ৳ 50.00 (5 x 10: ৳ 2,500.00)
Strip Price: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tacrolimus monohydrate oral |
| Company | Sandoz a novartis division |
| Also available as |
Indications
- Prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants
Pharmacology
- Binds to FKBP-12
- Inhibition of calcineurin phosphatase activity
- Inhibition of cytokine expression and production
- Inhibition of T-lymphocyte activation and proliferation
Dosage & Administration
- Recommended oral starting doses
- Different initial doses for liver, heart, kidney, and lung transplant patients
- Dosage recommendations for adults and children
- Recommendations for different transplant types and medications combinations
Interaction
- Interaction with Mycophenolic Acid Products
- Interaction with Nelfinavir and Grapefruit Juice
- Interaction with CYP3A Inhibitors
- Interaction with CYP3A4 Inducers
- Need for therapeutic drug monitoring and dose adjustment when co-administered with cannabidiol
Contraindications
- Hypersensitivity to tacrolimus or HCO-60 (polyoxyl 60 hydrogenated castor oil)
Side Effects
- Common adverse reactions such as abnormal renal function, hypertension, diabetes mellitus, fever, tremor, hyperglycemia, leukopenia, and more
Pregnancy & Lactation
- Potential fetal harm
- Advice to pregnant women about potential risk to the fetus
Precautions & Warnings
- Recognition of Crilomus capsules by patients or caregivers
- Monitoring of blood glucose for new onset diabetes after transplant
- Caution with nephrotoxic drugs
- Monitoring for neurologic abnormalities
- Serum potassium levels monitoring
- Requirement for antihypertensive therapy
- Observation for anaphylactic reactions with IV formulation
- Avoidance of live vaccines
- Consideration for discontinuation in certain conditions
- Risk of thrombotic microangiopathy and purpura
Overdose Effects
- Reported acute overdosages and associated adverse reactions
- Use of activated charcoal and general supportive measures for treatment
Therapeutic Class
- Drugs affecting the immune response
Storage Conditions
- Store below 30°C, dry place, away from light and moisture
- Keep out of the reach of children