Mabthera 10 mg/ml (IV Infusion)
100 mg vial: ৳ 12,175.79
Medicine Details
| Category | Details |
|---|---|
| Generic | Rituximab |
| Company | Roche bangladesh ltd |
| Also available as |
Indications
- Non-Hodgkin’s Lymphoma (NHL)
- Rheumatoid Arthritis (RA)
- Granulomatosis with Polyangiitis (GPA)
- Microscopic Polyangiitis (MPA)
- Pemphigus Vulgaris (PV)
Dosage & Administration
- Intravenous Infusion
- First Infusion
- Subsequent Infusions
- Recommended Dose for Non-Hodgkin’s Lymphoma (NHL)
- Recommended Dose for Chronic Lymphocytic Leukemia (CLL)
- Recommended Dose for Rheumatoid Arthritis (RA)
- Maintenance treatment
- Treatment of relapse
Pharmacology
- Chimeric murine/human monoclonal IgG1 kappa antibody
- CD20 antigen
- Molecular weight of 145 kD
- Binding affinity of approximately 8.0 nM
Interaction
- Formal drug interaction studies not performed
- No alteration of systemic exposure to fludarabine or cyclophosphamide in patients with CLL
Contraindications
- Known hypersensitivity to Rituximab or any other components
Side Effects
- Reactivation of hepatitis B virus
- Fever and rigors
- Pruritus
- Skin rashes
- Dyspnoea
- Bronchospasm
- Angioedema
- Transient hypotension
- Flushing
- Asthenia
- Headache
- Thrombocytopenia
- Neutropenia
- Anaemia
- Abdominal pain
- Bowel obstruction
- Perforation
- Exacerbation of heart failure and angina pectoris
- Reversible interstitial pneumonia and interstitial fibrosis
- Depletion of immunoglobulin concentrations
Pregnancy & Lactation
- Fetal harm when administered to a pregnant woman
- Adverse developmental outcomes including B-cell lymphocytopenia in infants
- Limited data on the presence of Rituximab in human milk
- Excretion in human breast milk
- Women advised not to breastfeed during treatment and for 6 months after the last dose
Precautions & Warnings
- Severe, including fatal, infusion-related reactions
- Severe mucocutaneous reactions
- Progressive Multifocal Leukoencephalopathy (PML)
- Tumor Lysis Syndrome (TLS)
- Infections
Therapeutic Class
- Cytotoxic immunosuppressants
Storage Conditions
- Stored at 2°C-8°C in a refrigerator
- Do not freeze
- Protect from light
- Keep out of the reach of children