Femara 2.5 mg (Tablet)

Unit Price: ৳ 113.38 (3 x 10: ৳ 3,401.40)
Strip Price: ৳ 1,133.80

Medicine Details

Category Details
Generic Letrozole
Company Novartis bangladesh ltd

Indications

  • Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
  • First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
  • Treatment of advanced breast cancer in women with postmenopausal status
  • Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer
  • Allows subsequent breast-conserving surgery in women not originally considered candidates for this type of surgery

Pharmacology

  • Mechanism of Action: Potent and highly specific nonsteroidal aromatase inhibitor
  • Effect on Estrogen Biosynthesis in Postmenopausal Women: Suppression of estrogen biosynthesis in all tissues
  • Pharmacokinetics:
    • Absorption: Rapid and complete absorption from the gastrointestinal tract
    • Plasma Protein Binding: Approximately 60%, mainly to albumin
    • Metabolic Clearance: Slow relative to hepatic blood flow
    • Terminal Elimination Half-Life: About 2 days

Dosage & Administration

  • Recommended Dose for Adult and Elderly Patients: 2.5 mg once daily
  • Duration of Treatment: 5 years in adjuvant and extended adjuvant setting
  • No Dose Adjustment Required for Elderly Patients: 1
  • Dosage in Patients with Hepatic and/or Renal Impairment: No adjustment required for patients with renal impairment

Interaction

No clinically significant drug reactions observed with cimetidine and warfarin

Contraindications

  • Known or suspected hypersensitivity to letrozole or other aromatase inhibitors
  • Pregnancy, lactation, and pre-menopausal women
  • Severe hepatic dysfunction

Side Effects

  • Common:
    • Hot flushes
    • Increased cholesterol levels
    • Fatigue
    • Increased sweating
    • Pain in bones and joints
    • Skin rash
    • Headache
    • Dizziness
    • Nausea
    • Vomiting
    • Indigestion
    • Constipation
    • Diarrhea
    • Osteoporosis
    • Swelling of limbs
    • Depression
    • Weight increase
    • Hair loss
    • High blood pressure
    • Abdominal pain
    • Dry skin
    • Vaginal bleeding
    • Palpitations
    • Joint stiffness
    • Chest pain
  • Rare:
    • Anxiety
    • Nervousness
    • Blurred vision
    • Insomnia
    • Carpal tunnel syndrome
    • Impairment of sensation
    • Skin itching
    • Dryness of mucous membranes
    • Weight decrease
    • Urinary tract infection
    • Increased frequency of urination
    • Cough
    • Elevated enzyme levels
    • Yellowing of the skin and eyes
    • High bilirubin levels

Pregnancy & Lactation

  • Teratogenicity in Rats: Observed at certain doses
  • Use in Pregnant Women: Not recommended due to inadequate studies
  • Excretion in Human Milk: Not known, should not be administered to nursing women

Precautions & Warnings

  • No dosage adjustment necessary in breast cancer patients with moderate hepatic dysfunction
  • Renal impairment (calculated creatinine clearance: 20 to 50 ml/min) did not affect steady-state plasma letrozole concentration
  • Possible fatigue and dizziness
  • Caution in operating machinery or driving a car

Overdose Effects

No clinical experience of overdosage, no specific antidote

Therapeutic Class

Hormonal Chemotherapy

Storage Conditions

Keep below 30°C temperature, away from light & moisture, keep out of the reach of children

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