Letrol 2.5 mg (Tablet)
Unit Price: ৳ 42.00 (2 x 5: ৳ 420.00)
Strip Price: ৳ 210.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Letrozole |
| Company | Renata limited |
Indications
- Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
- First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
- Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer
- Treatment of advanced breast cancer in women with natural or induced postmenopausal status
Pharmacology
- Mechanism of Action: Inhibition of aromatase enzyme
- Estrogen biosynthesis reduction in all tissues
- Effect on estrogen-dependent breast cancer cells
- Suppression of estrogen biosynthesis in peripheral and malignant tissues
- Impact on postmenopausal women's estrogen levels
- Pharmacokinetics: Absorption, protein binding, metabolic clearance, and half-life
Dosage & Administration
- Recommended daily dose: 2.5mg
- Duration of treatment in adjuvant and metastatic settings
- No dose adjustment for elderly patients
- No dosage adjustment for hepatic and/or renal impairment
- Special considerations for severe hepatic impairment
- Not applicable for children
Interaction
- Clinical interaction with cimetidine and warfarin
- Co-administration effects
Contraindications
- Hypersensitivity to letrozole or other aromatase inhibitors
- Contradicted during pregnancy and lactation
- Severe hepatic dysfunction
Side Effects
- Common and rare side effects
- Physical and mental effects on patients
- Impact on various body systems
Pregnancy & Lactation
- Teratogenicity and foetotoxicity in pregnant rats
- Embryotoxicity and foetotoxicity
- Not recommended for pregnant and nursing women
Precautions & Warnings
- Hepatic and renal impairment considerations
- Fatigue and dizziness observations
- Operational impairment advice to patients
Overdose Effects
- Lack of clinical experience
- Absence of specific antidote
- Possible supportive care and monitoring
Therapeutic Class
- Hormonal Chemotherapy
Storage Conditions
- Temperature, light, and moisture considerations
- Safekeeping away from children