Loreta 2.5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Letrozole |
| Company | Popular pharmaceuticals ltd |
Title and Categories
- Letrozole Medicine
- Postmenopausal Women's Medicine
- Breast Cancer Treatment
- Hormonal Chemotherapy
Dimensions
Color Options
Functions
- Adjuvant treatment of hormone receptor positive early breast cancer
- First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
- Treatment of advanced breast cancer in women with postmenopausal status
- Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer
Materials
Technical Specifications
- Mechanism of Action: Potent and highly specific nonsteroidal aromatase inhibitor
- Pharmacokinetics: Rapid and complete absorption from the gastrointestinal tract, 99.9% absolute bioavailability, plasma protein binding of approximately 60%, slow metabolic clearance, apparent terminal elimination half-life in plasma about 2 days
Design Elements
Usability Features
- Dosage & Administration: Recommended dose of 2.5 mg once daily for adults and elderly patients, treatment continuity based on specific patient scenarios, no dosage adjustment for hepatic and/or renal impairment, not applicable for children
Indications
- Adjuvant treatment of hormone receptor positive early breast cancer
- First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
- Treatment of advanced breast cancer in women with postmenopausal status
- Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer
Interaction
Clinical interaction studies with cimetidine and warfarin indicated that co-administration of Loreta with these drugs does not result in clinically significant drug reactions
Contraindications
Contraindicated in known or suspected hypersensitivity to letrozole, other aromatase inhibitors, or to any of their ingredients, during pregnancy, lactation, in pre-menopausal women, and in severe hepatic dysfunction
Side Effects
- Common:
- Hot flushes
- Increased level of cholesterol
- Fatigue
- Increased sweating
- Pain in bones and joints
- Skin rash
- Headache
- Dizziness
- Malaise
- Gastrointestinal disorders
- Thinning or wasting of bones
- Swelling of arms, hands, feet, ankles
- Depression
- Weight increase
- Hair loss
- Raised blood pressure
- Abdominal pain
- Rare:
- Nervous disorders
- Memory problems
- Insomnia
- Pain or burning sensation in the hands or wrist
- Impairment of sensation
- Eye disorders
- Skin disorders
- Vaginal discharge or dryness
- Urinary tract infection
- Cough
- High blood levels of bilirubin
Pregnancy & Lactation
Not recommended for pregnant women or nursing women
Precautions & Warnings
Caution advised in breast cancer patients with moderate hepatic dysfunction, no dose adjustment for renal impairment (calculated creatinine clearance: 20 to 50 ml/min), potential risks and benefits to be considered carefully before prescribing
Overdose Effects
No clinical experience of overdosage, no specific antidote, dialysis may be helpful, emesis may be induced if the patient is alert, supportive care and frequent monitoring of vital signs are appropriate
Therapeutic Class
Hormonal Chemotherapy
Storage Conditions
Keep below 30°C temperature, away from light & moisture, keep out of the reach of children