Zoleta 2.5 mg (Tablet)
Unit Price: ৳ 43.00 (2 x 5: ৳ 430.00)
Strip Price: ৳ 215.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Letrozole |
| Company | Nuvista pharma ltd |
Indications
- Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
- First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
- Treatment of advanced breast cancer in women with natural or artificially induced postmenopausal status
- Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer
Pharmacology
- Potent and highly specific nonsteroidal aromatase inhibitor
- Inhibits the aromatase enzyme by competitively binding to the haem of the cytochrome P450 subunit of the enzyme
- Suppresses serum oestrone and oestradiol
- Rapid and complete absorption from the gastrointestinal tract
- Metabolic clearance to a pharmacologically inactive carbinol metabolite
Dosage & Administration
- Recommended dose of Letrozole is 2.5 mg once daily
- No dose adjustment required for elderly patients
- No dosage adjustment required for patients with hepatic and/or renal impairment
- Treatment should continue for 5 years in adjuvant and extended adjuvant setting
- No dose adjustment required for patients with renal impairment (creatinine clearance =10 mL/min)
Interaction
- No clinically significant drug reactions with co-administration of Zoleta with cimetidine and warfarin
Contraindications
- Contraindicated in known or suspected hypersensitivity to letrozole
- Contraindicated during pregnancy and lactation
- Contraindicated in severe hepatic dysfunction
Side Effects
- Common: Plot flushes, Increased level of cholesterol, Fatigue, Increased sweating, Pain in bones and joints, Skin rash, Fleadache, Dizziness
- Rare: Nervous disorders, Memory problems, Eye disorders, Weight decrease, Urinary tract infection
Pregnancy & Lactation
- Teratogenicity and maternal toxicity seen in pregnant rats with oral administration of letrozole
- Not recommended for use in pregnant women
- Should not be administered to a nursing woman
Precautions & Warnings
- No dosage adjustment necessary in breast cancer patients with moderate hepatic dysfunction
- No dose adjustment necessary for renal impairment (calculated creatinine clearance: 20 to 50 ml/min)
- Physical and/or mental abilities required for operating machinery or driving a car may be impaired
Overdose Effects
- No clinical experience of overdosage
- No specific antidote to Zoleta
- Dialysis may be helpful due to low protein binding
- Supportive care and frequent monitoring of vital signs is appropriate
Therapeutic Class
- Hormonal Chemotherapy
Storage Conditions
- Keep below 30°C temperature, away from light & moisture
- Keep out of the reach of children