Endofree 2.5 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 5: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Letrozole |
| Company | Incepta pharmaceuticals ltd |
Indications
- Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
- Adjuvant treatment of postmenopausal women with early breast cancer
- First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
- Treatment of advanced breast cancer in women with natural or artificially induced postmenopausal status
- Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer
Pharmacology
- Mechanism of Action - Aromatase inhibition
- Estrogen suppression in postmenopausal women
- Suppression of estrogen biosynthesis in peripheral and malignant tissues
- Plasma concentration suppression of estrogen and androgenic precursors
- Metabolic clearance and elimination half-life
- Plasma protein binding and absorption
Dosage & Administration
- Recommended dose of 2.5mg once daily
- Treatment duration in various cancer settings
- No dose adjustment required for elderly patients
- No dose adjustment for patients with hepatic or renal impairment
- Special supervision for severe hepatic impairment
- Not applicable for children
Interaction
- Clinical interaction studies with cimetidine and warfarin
- Co-administration with other drugs
- Impact on cytochrome P450 isoenzymes
Contraindications
- Known or suspected hypersensitivity
- Contraindicated during pregnancy and lactation
- Contraindicated in pre-menopausal women
- Contraindicated in severe hepatic dysfunction
Side Effects
- Common and rare side effects
- Physical and mental impairment caution
- Impact on cholesterol levels and blood pressure
- Gastrointestinal and musculoskeletal effects
- Nervous, skin, eye, and urinary disorders
Pregnancy & Lactation
- Teratogenicity and embryotoxicity in animal studies
- Not recommended for pregnant and nursing women
- Excretion in human milk
Precautions & Warnings
- Caution in moderate hepatic dysfunction
- No dose adjustment needed for renal impairment
- Consideration for dialysis in weakly bound cases
- Potential impairment of mental and physical abilities
Overdose Effects
- Absence of clinical experience
- Non-specific antidote and supportive care
- Potential effect on vital signs
- Low protein binding and possible dialysis
Therapeutic Class
- Hormonal Chemotherapy
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of reach of children