Letrogen 2.5 mg (Tablet)

Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00

Medicine Details

Category Details
Generic Letrozole
Company Ibn sina pharmaceuticals ltd

Indications

  • Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
  • First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
  • Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer

Pharmacology

  • Mechanism of Action: Letrozole is a potent and highly specific nonsteroidal aromatase inhibitor.
  • Estrogen Suppression: Reduces estrogen biosynthesis in all tissues
  • Pharmacokinetics: Rapid and complete absorption from the gastrointestinal tract

Dosage & Administration

  • Recommended Dose: 2.5 mg once daily
  • Treatment Duration: 5 years in adjuvant setting, or until tumor relapse occurs

Interaction

Co-administration studies with cimetidine and warfarin showed no clinically significant drug reactions

Contraindications

  • Known or suspected hypersensitivity to letrozole
  • Pregnancy, lactation, pre-menopausal women
  • Severe hepatic dysfunction

Side Effects

  • Common:
    • Hot flushes
    • Increased level of cholesterol
    • Fatigue
    • Pain in bones and joints
    • Skin rash
    • Headache
    • Gastrointestinal disorders
    • Osteoporosis
    • Depression
    • Weight increase
  • Rare:
    • Nervous disorders
    • Carpal tunnel syndrome
    • Eye disorders
    • Skin disorders
    • Urinary tract infection

Pregnancy & Lactation

  • Teratogenicity in Rats: Embryotoxicity and foetotoxicity observed at higher doses
  • Recommendation: Not recommended for use in pregnant or nursing women

Precautions & Warnings

  • Hepatic Dysfunction: Caution recommended
  • Renal Impairment: No dose adjustment necessary
  • Mental Abilities: May be impaired; caution while operating machinery or driving

Overdose Effects

No clinical experience; supportive care and monitoring recommended

Therapeutic Class

Hormonal Chemotherapy

Storage Conditions

Keep below 30°C temperature, away from light & moisture

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